8-Br-cGMP

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产品名称: 8-Br-cGMP

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简单介绍

CAS:51116-01-9Formula:C10H10BrN5O7P.NaMW:446.08Appearance:Whitetooff-whiteSolidPurity:95%byTLC

8-Br-cGMP 的详细介绍

A cell-permeable cGMP analog having greater resistance to hydrolysis by phosphodiesterases than cGMP. Activates cGMP-dependent protein kinase (PKG), slows or inhibits the intracellular calcium oscillations of tracheal smooth muscle cells in response to acetylcholine. It inhibits thrombin stimulated arachidonic acid release in human platelets.

Additional Information

Synonyms	8- Bromoguanosine- 3', 5'- cyclic monophosphate, cyclic 8- bromoguanosine- 3', 5'- monophosphate, 8- bromoguanosine- 3', 5'-monophosphate
Product #	B-2174
CAS #	51116-01-9
Chemical Name	8- Bromoguanosine- 3', 5'- cyclic monophosphate, cyclic 8- bromoguanosine- 3', 5'- monophosphate, 8- bromoguanosine- 3', 5'-monophosphate
Formula	C₁₀H₁₀BrN₅O₇P. Na
MW	446.08
Appearance	White to off-white Solid
Purity	95% by TLC
Solubility	Soluble in H₂O (~25 mg/ml) or aqueous buffers
Storage Temp	-20°C
Use	A cell-permeable cGMP analog resistance to hydrolysis than cGMP

Additional Information

MDL Number	MFCD00070128
InChI	InChI=1S/C10H11BrN5O7P.Na/c11-9-13-3-6(14-10(12)15-7(3)18)16(9)8-4(17)5-2(22-8)1-21-24(19,20)23-5;/h2,4-5,8,17H,1H2,(H,19,20)(H3,12,14,15,18);/q;+1/p-1/t2-,4-,5-,8-;/m1./s1
SMILES	C1[C@@H]2[C@H]([C@H]([C@@H](O2)n3c4c(c(=O)[nH]c(n4)N)nc3Br)O)OP(=O)(O1)[O-].[Na+]

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