8-Br-cAMP

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产品名称: 8-Br-cAMP

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简单介绍

CAS:76939-46-3Formula:C10H10BrN5O6P.NaMW:430.08Appearance:Whitetooff-whiteSolidPurity:98%byTLC

8-Br-cAMP 的详细介绍

A cell-permeable cAMP analog that is more resistant to hydrolysis by phosphodiesterases than cAMP. Activates protein kinase A, inhibits growth, decreases proliferation, increases differentiation, and induces apoptosis of cultured cells. Also recently shown to improve the reprogramming efficiency of human neonatal foreskin fibroblast (HFF1) cells 2-fold.

Additional Information

Synonyms	8- Bromoadenosine- 3', 5'- cyclic monophosphate; cyclic 8- bromoadenosine- 3', 5'- monophosphate; 8- bromoadenosine- 3', 5'-Monophosphate
Product #	B-2173
CAS #	76939-46-3
Chemical Name	8- Bromoadenosine- 3', 5'- cyclic monophosphate; cyclic 8- bromoadenosine- 3', 5'- monophosphate; 8- bromoadenosine- 3', 5'-Monophosphate
Formula	C₁₀H₁₀BrN₅O₆P. Na
MW	430.08
Appearance	White to off-white Solid
Purity	98% by TLC
Solubility	Soluble in H₂O (~100 mg/ml)
Melting Point	233.9-235 °C
Storage Temp	-20°C
Use	A cell-permeable cAMP analog that is more resistant to hydrolysis by phosphodiesterases than cAMP

Additional Information

MDL Number	MFCD00005844
ChemACX	X1087628-1
InChI	InChI=1S/C10H11BrN5O6P.Na/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-5(17)6-3(21-9)1-20-23(18,19)22-6;/h2-3,5-6,9,17H,1H2,(H,18,19)(H2,12,13,14);/q;+1/p-1/t3-,5-,6-,9-;/m1./s1
SMILES	c1nc(c2c(n1)n(c(n2)Br)[C@H]3[C@@H]([C@H]4[C@H](O3)COP(=O)(O4)[O-])O)N.[Na+]

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