6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide

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产品名称: 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide

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简单介绍

CAS:49843-98-3Formula:C13H13ClN2OMW:248.71Appearance:WhiteSolidPurity:97%byHPLC

6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 的详细介绍

A potent SIRT1 inhibitor (IC= 38 nM). EX-527 is 200-500-fold more selective for SIRT1 than for SIRT2 or SIRT3. Does not inhibit SIRT4-7, does not inhibit class I/II HDAC activity at concentrations up to 100M. Enhances p53 acetylation in response to DNA damaging agents.

Additional Information

Synonyms	EX-527
Product #	S-2432
CAS #	49843-98-3
Chemical Name	EX-527, 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
Formula	C₁₃H₁₃ClN₂O
MW	248.71
Appearance	White Solid
Purity	97% by HPLC
Solubility	Soluble in DMSO (20 mg/ml)
Storage Temp	+4°C
Therapeutic Area	Neurological Disorders
Use	A selective inhibitor of SIRT1 over SIRT2 and SIRT3 for the Treatment of Huntington’s Disease

Additional Information

MDL Number	MFCD03009471
ChemACX	X1520276-1
InChI	InChI=1S/C13H13ClN2O/c14-7-4-5-11-10(6-7)8-2-1-3-9(13(15)17)12(8)16-11/h4-6,9,16H,1-3H2,(H2,15,17)
SMILES	c1cc2c(cc1Cl)c3c([nH]2)C(CCC3)C(=O)N

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