6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide

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产品名称: 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide

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简单介绍

CAS:49843-98-3Formula:C13H13ClN2OMW:248.7Appearance:WhitetoTanPowderPurity:95%

6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 的详细介绍

Specific cell permeable inhibitor. Potent cell permeable and metabolically stable specific inhibitor of hSIRT1 (IC=98nM in vivo / IC=38nM in vitro; compared to hSIRT2: IC=19M and hSIRT3: IC=48M) with no effect on human histone deacetylases (HDACs) class I and class II, nor NAD glycohydrolase (IC100g). Inhibits the deacetylation of p53 (IC=1M).

Additional Information

Synonyms	EX-527
Product #	C-1445
CAS #	49843-98-3
Chemical Name	6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
Formula	C₁₃H₁₃ClN₂O
MW	248.7
Appearance	White to Tan Powder
Purity	95%
Solubility	Soluble in DMSO (10mg/ml).
Storage Temp	-20°C
Therapeutic Area	Neurological Disorders
Use	A selective inhibitor of SIRT1 over SIRT2 and SIRT3 for the Treatment of Huntington’s Disease

Additional Information

MDL Number	MFCD03009471
ChemACX	X1520276-1
InChI	InChI=1S/C13H13ClN2O/c14-7-4-5-11-10(6-7)8-2-1-3-9(13(15)17)12(8)16-11/h4-6,9,16H,1-3H2,(H2,15,17)
SMILES	c1cc2c(cc1Cl)c3c([nH]2)C(CCC3)C(=O)N

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