5-Methylcytidine CAS 2140-61-6 DNA Methylation Research

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产品名称: 5-Methylcytidine CAS 2140-61-6 DNA Methylation Research

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简单介绍

CAS:2140-61-6Formula:C10H15N3O5MW:257.2Appearance:LightYellowCrystalsPurity:99%

5-Methylcytidine CAS 2140-61-6 DNA Methylation Research 的详细介绍

5-Methylcytidine is a modified nucleoside derived from 5-methylcytosine. It has been used in epigenetics research, especially in studies involving DNA methylation processes including genomic imprinting and the control of gene expression and differentiation.

The presence of 5-methylcytidine (m⁵C) in tRNA and rRNA molecules of a wide variety of organisms was first observed more than 40 years ago. Recent studies in eukaryotes have shown that mRNA modifications such as RNA-editing (conversion of an adenosine base to inosine), N6-adenine methylation (m⁶A), and 5-methylcytidine (m⁵C) can change the coding sequence, alter splicing patterns, or change RNA stability. 5-methylcytidine (m⁵C) is a modification that occurs both on DNA and RNA. In eukaryotes, this DNA modification has been extensively studied over the past years, and has been found to play a crucial role in genomic imprinting, X-chromosome inactivation, and suppression of repetitive elements.

Additional Information

Product #	M-1106
CAS #	2140-61-6
Chemical Name	4-AMINO-1-[(2R,3R,4S,5R)-3,4-DIHYDROXY-5-(HYDROXYMETHYL)OXOLAN-2-YL]-5-METHYLPYRIMIDIN-2-ONE
Formula	C₁₀H₁₅N₃O₅
MW	257.2
Appearance	Light Yellow Crystals
Purity	99%
Solubility	Soluble in Water (10 mg/ml)
Storage Temp	-20°C
Use	Methylated DNA base

Additional Information

Merck Index	Merck Index: 13. .2001
MDL Number	MFCD00006548
ChemACX	X1014453-1
InChI	InChI=1S/C10H15N3O5/c1-4-2-13(10(17)12-8(4)11)9-7(16)6(15)5(3-14)18-9/h2,5-7,9,14-16H,3H2,1H3,(H2,11,12,17)/t5-,6-,7-,9-/m1/s1
SMILES	Cc1cn(c(=O)nc1N)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O

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