5-Azacytidine

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产品名称: 5-Azacytidine

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简单介绍

CAS:320-67-2Formula:C8H12N4O5MW:244.3g/molAppearance:Whitetooff-whiteSolidPurity:98%byTLC

5-Azacytidine 的详细介绍

A potent growth inhibitor and cytotoxic agent; a potent DNA methyltransferase inhibitor.Causes DNA demethylation or hemi-demethylation, creating openings that allow transcription factors to bind to DNA and reactivate tumor suppressor genes. Also recently shown to increase the reprogramming efficiency of stem cells to 10-fold.

Additional Information

Synonyms	Ladakamycin, Vidaza, Azadine
Product #	A-2172
CAS #	320-67-2
Chemical Name	4-Amino-1-(β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one
Formula	C₈H₁₂N₄O₅
MW	244.3 g/mol
Appearance	White to off-white Solid
Purity	98% by TLC
Solubility	Soluble in AcOH (5 mg/ml)
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	5-Azacytidine is a potent growth inhibitor and a cytotoxic agent

Additional Information

MDL Number	MFCD00006539
ChemACX	X1005308-2
InChI	InChI=1S/C8H12N4O5/c9-7-10-2-12(8(16)11-7)6-5(15)4(14)3(1-13)17-6/h2-6,13-15H,1H2,(H2,9,11,16)/t3-,4-,5-,6-/m1/s1
SMILES	c1nc(nc(=O)n1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)N

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