5-Aza-2'-deoxycytidine

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产品名称: 5-Aza-2'-deoxycytidine

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简单介绍

CAS:2353-33-5Formula:C8H12N4O4MW:228.08Appearance:Whitetooff-whiteSolidPurity:98%byHPLC

5-Aza-2'-deoxycytidine 的详细介绍

An epigenetic modifier. Decitabine is an analogue of the nucleoside 2-deoxycytidine. It is believed to exert its antineoplastic effects after phosphorylation and direct incorporation into DNA and inhibition of DNA methyltransferase, causing hypomethylation of DNA and cellular differentiation or apoptosis. DNA hypomethylation is achieved at concentrations below those required to significantly inhibit DNA synthesis, which may promote restoration of function to genes associated with control of cellular differentiation and proliferation.

Additional Information

Synonyms	Decitabine
Product #	A-2171
CAS #	2353-33-5
Chemical Name	4-amino-1-(2-deoxy-β-D-erythro-pentofuranosyl) 1,3,5-triazin-2(1H)-one; Decitabine
Formula	C₈H₁₂N₄O₄
MW	228.08
Appearance	White to off-white Solid
Purity	98% by HPLC
Solubility	DMSO (25 mg/ml), 50% acetic acid (25 mg/ml)
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	It is used as anticancer agent

Additional Information

MDL Number	MFCD00043011
ChemACX	X1013593-6
InChI	InChI=1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)/t4-,5+,6+/m0/s1
SMILES	c1nc(nc(=O)n1[C@H]2C[C@@H]([C@H](O2)CO)O)N

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