(R,S)-Rolipram, Inhibitor of PDE IV

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产品名称: (R,S)-Rolipram, Inhibitor of PDE IV

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简单介绍

CAS:61413-54-5Formula:C16H21N03MW:275.4Appearance:WhiteSolidPurity:>99%

(R,S)-Rolipram, Inhibitor of PDE IV 的详细介绍

Rolipram is a selective phosphodiesterase-4 inhibitor discovered and developed by Schering AG as a potential antidepressant drug in the early 1990s. It was previously used as an antideppresant but was discontinued because of its serious side effects. Rolipram has shown to boost the levels of NMNAT2 (Nicotinamide mononeucleotide adenylyl transferase 2), an enzyme that blocks the processes associated with dementia - a form of Alzheimers. In other studies it has shown to breakdown misfolded tau proteins.

Additional Information

Synonyms	ZK-62711
Product #	R-1012
CAS #	61413-54-5
Chemical Name	(R,S)-4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one
Formula	C₁₆H₂₁N₀₃
MW	275.4
Appearance	White Solid
Purity	> 99%
Solubility	Soluble in Water
Melting Point	132°C
Storage Temp	Store at +4°C under desiccating conditions.
Use	Used in Neurodegenrative Disease research as a PDE4 inhibitor.

Additional Information

Merck Index	13.8332.2001
MDL Number	MFCD00270906
ChemACX	X1038250-2
InChI	InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)
SMILES	COc1ccc(cc1OC2CCCC2)C3CC(=O)NC3

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