(-)-Arctiin, Arctium lappa

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产品名称: (-)-Arctiin, Arctium lappa

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简单介绍

CAS:20362-31-6Formula:C27H34O11MW:534.6Appearance:Whitetooff-whiteSolidPurity:95%byHPLC

(-)-Arctiin, Arctium lappa 的详细介绍

Lignan derivative with anti-tumor activities. Down-regulates anti-apoptotic protein Bcl-XL. Potent inhibitor of HIV Type-I Integrase and DNA topoisomerase II. Shows phytoestrogenic activity and is an antagonist for platelet activating factor and Ca2+.

Additional Information

Synonyms	Arctigenin-4-glucoside
Product #	A-1306
CAS #	20362-31-6
Chemical Name	(3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]-3-[[4-(β-D-glucopyranosyloxy)-3-methoxyphenyl]methyl]dihydro-2(3H)-furanone
Formula	C₂₇H₃₄O₁₁
MW	534.6
Appearance	White to off-white Solid
Purity	95% by HPLC
Solubility	Soluble in DMSO (5mg/ml); sparingly soluble in water.
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	Arctiin has shown to be a suppressor of cyclin D1 protein expression in multiple types of human tumor cells, such as osteosarcoma, lung, colorectal, cervical, breast, melanoma, and prostate cancer

Additional Information

MDL Number	MFCD00870630
ChemACX	X1536500-9
InChI	InChI=1S/C27H34O11/c1-33-18-6-4-14(10-20(18)34-2)8-16-13-36-26(32)17(16)9-15-5-7-19(21(11-15)35-3)37-27-25(31)24(30)23(29)22(12-28)38-27/h4-7,10-11,16-17,22-25,27-31H,8-9,12-13H2,1-3H3/t16-,17+,22+,23+,24-,25+,27+/m0/s1
SMILES	COc1ccc(cc1OC)C[C@H]2COC(=O)[C@@H]2Cc3ccc(c(c3)OC)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O

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