(+)-Aphidicolin Nigrospora oryzae

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产品名称: (+)-Aphidicolin Nigrospora oryzae

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简单介绍

CAS:38966-21-1Formula:C20H34O4MW:338.5Appearance:Off-WhitePowderPurity:>99%

(+)-Aphidicolin Nigrospora oryzae 的详细介绍

Aphidicolin is a reversible Inhibitor of eukaryotic nuclear DNA replication. cell cycle at early S-phase.N K-independent Activation of c-Jun during Neuronal Apoptosis Induced by Multiple DNA-damaging Agents. DNA AND CHROMOSOMES: Cohesin Acetylation Promotes Sister Chromatid Cohesion Only in Association with the Replication Machinery. CELL BIOLOGY: RET Modulates Cell Adhesion via its Cleavage by Caspase in Sympathetic Neurons.

Low dose aphidicolin is an inhibitor of the DNA replicative polymerases α , δ, and ε¹. Aphidicolin is a potent and specific inhibitor of B-family DNA polymerases².

1.) http://www.jbc.org/content/290/48/28953.full.pdf+html

2.) http://nar.oxfordjournals.org/content/42/22/14013.full.pdf

Additional Information

Synonyms	APH
Product #	A-1026
CAS #	38966-21-1
Chemical Name	(3-α,4-α,5-α,17-α)-3,17-Dihydroxy-4-methyl-9,15-cyclo-C,18-dinor-14,15-secoandrostane-4,17-dimethanol
Formula	C₂₀H₃₄O₄
MW	338.5
Appearance	Off-White Powder
Purity	>99%
Solubility	Methanol: Clear colorless solution at 10 mg/ml
Melting Point	230°C
Storage Temp	+4°C

Additional Information

Merck Index	Merck Index: 13.734.2001
MDL Number	MFCD00083214
ChemACX	X1001937-7
InChI	InChI=1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1
SMILES	C[C@]12CC[C@H]([C@@]([C@@H]1CC[C@@H]3[C@@]24CC[C@@]([C@H](C3)C4)(CO)O)(C)CO)O

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