Anti-APC–AAT complexes, neoepitope (human) ABS 001-07

Mouse monoclonal antibody

ABS 001-07 is specific for a conformation-dependent neoepitope that is expressed in activated protein C upon complex-formation with α1-antitrypsin. No reaction is seen to non-complexed α1-antitrypsin and only very little cross reaction to protein C zymogen. Note that specificity is calcium dependent.

Recombinant human activated protein C

IgG1/k

ABS 001-07 is specific for a conformation-dependent neoepitope that is expressed in activated protein C upon complex-formation with α1-antitrypsin. 

Available in 200 µL and 1 mL size.1 mg/mL +/- 15%. See Certificate of Analysis for details.

Protein C is a vitamin K-dependent serine protease produced in the liver and made up of 2 polypeptide chains. The 62kDa proenzyme is activated by thrombin and the active enzyme cleaves factor Va and VIIIa and thus inhibits blood coagulation. The molecular weight of the active enzyme is 55kDa and the normal concentrations in human plasma is approximately 1-3 ng/ml because of the very fast turnover, the proenzyme concentration is approximately 3 µg/ml. The activated protein C (APC) is inhibited by members of the serine protease inhibitor (serpin) family, of which α1-antitrypsin (AAT) and protein C inhibitor (PCI) are the most important.