CD8 Biotin Antibody

CD8, MAL, p32.

Rat Anti Mouse Monoclonal.

CD8 is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. CD8 acts as a co-receptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional CD8 is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains.
CD8 identifies cytotoxic/suppressor t-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of t-cell mediated killing. CD8 alpha chains bind to class-I MHC molecules alpha-3 domains.

NYRmCD8.

Purified Mouse LN T cells.

Rat IgM.

Ion Exchange Column.

1mg/ml in PBS (after reconstitution).

Lyophilized: store at 4°C. After reconstitution, if not intended for use within a month, aliquot and store at -20°C.

Reconstitute with of H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.

FACS staining, immunohistochemistry, Western Blotting. For staining, use 10 µl/1,000,000 cells.

This antibody is only available unconjugated and conjugated to FITC.

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.