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Anti-FBXO11 Antibody

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产品名称: Anti-FBXO11 Antibody
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简单介绍

Anti-FBXO11 Antibody


Anti-FBXO11 Antibody  的详细介绍
Name: Anti-FBXO11 Antibody
See all FBXO11 primary antibodies
Description: Rabbit polyclonal antibody to FBXO11
Specificity: The antibody detects endogenous level of total FBXO11 antibody.
Applications: WB, IF
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human FBXO11.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antibodies were purified by affinity purification using immunogen.
Concentration: 1.0mg / ml
Formulation: Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20˚C
Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.
Tissue Specificity: Isoform 5 is expressed in keratinocytes, fibroblasts and melanocytes.
Cellular Location: Nucleus. Chromosome.
Database Links:
  • Entrez Gene: 80204 Human
  • Entrez Gene: 225055 Mouse
  • Entrez Gene: 301674 Rat
  • Omim: 607871 Human
  • SwissProt: Q86XK2 Human
  • SwissProt: Q7TPD1 Mouse
  • SwissProt: Q7TSL3 Rat
  • Unigene: 352677 Human
  • Unigene: 386857 Mouse
  • Unigene: 36585 Rat
    		•
    Synonyms:
  • F box only protein 11 Antibody
  • F box protein 11 Antibody
  • F-box only protein 11 Antibody
  • FBX11 Antibody
  • FBX11_HUMAN Antibody
  • FBXO11 Antibody
  • PRMT9 Antibody
  • Protein arginine N methyltransferase 9 Antibody
  • Ubiquitin protein ligase E3 component n recognin 6 Antibody
  • UBR6 Antibody
  • UG063H01 Antibody
  • VIT 1 Antibody
  • VIT-1 Antibody
  • VIT1 Antibody
  • Vitiligo associated protein 1 Antibody
  • Vitiligo associated protein VIT 1 Antibody
  • Vitiligo-associated protein 1 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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