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Anti-FBXO11 Antibody

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产品名称: Anti-FBXO11 Antibody
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简单介绍

Anti-FBXO11 Antibody


Anti-FBXO11 Antibody  的详细介绍
Name: Anti-FBXO11 Antibody
See all FBXO11 primary antibodies
Description: Rabbit polyclonal antibody to FBXO11
Specificity: FBXO11 pAb detects endogenous levels of FBXO11 protein.
Applications: WB, IHC, IF
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant full length Human FBXO11.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 94 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.
Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.
Tissue Specificity: Isoform 5 is expressed in keratinocytes, fibroblasts and melanocytes.
Cellular Location: Nucleus. Chromosome.
Database Links:
  • Entrez Gene: 80204?Human
  • Entrez Gene: 225055?Mouse
  • Entrez Gene: 301674?Rat
  • Omim: 607871?Human
  • SwissProt: Q86XK2?Human
  • SwissProt: Q7TPD1?Mouse
  • SwissProt: Q7TSL3?Rat
  • Unigene: 352677?Human
  • Unigene: 386857?Mouse
  • Unigene: 36585?Rat
    		•
    Synonyms:
  • F box only protein 11 Antibody
  • F box protein 11 Antibody
  • F-box only protein 11 Antibody
  • FBX11 Antibody
  • FBX11_HUMAN Antibody
  • FBXO11 Antibody
  • PRMT9 Antibody
  • Protein arginine N methyltransferase 9 Antibody
  • Ubiquitin protein ligase E3 component n recognin 6 Antibody
  • UBR6 Antibody
  • UG063H01 Antibody
  • VIT 1 Antibody
  • VIT-1 Antibody
  • VIT1 Antibody
  • Vitiligo associated protein 1 Antibody
  • Vitiligo associated protein VIT 1 Antibody
  • Vitiligo-associated protein 1 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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