产品资料

Anti-FBXO11 Antibody

如果您对该产品感兴趣的话,可以
产品名称: Anti-FBXO11 Antibody
产品型号:
产品展商: 其它品牌
产品文档: 无相关文档

简单介绍

Anti-FBXO11 Antibody


Anti-FBXO11 Antibody  的详细介绍
Name: Anti-FBXO11 Antibody
See all FBXO11 primary antibodies
Description: Rabbit polyclonal antibody to FBXO11.
Applications: WB, IHC, IF
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:100, IF: 1:20 - 1:100.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human FBXO11.
Protein Length: 927
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.
Tissue Specificity: Isoform 5 is expressed in keratinocytes, fibroblasts and melanocytes.
Cellular Location: Nucleus. Chromosome.
Database Links:
  • Entrez Gene: 80204?Human
  • Entrez Gene: 225055?Mouse
  • Entrez Gene: 301674?Rat
  • Omim: 607871?Human
  • SwissProt: Q86XK2?Human
  • SwissProt: Q7TPD1?Mouse
  • SwissProt: Q7TSL3?Rat
  • Unigene: 352677?Human
  • Unigene: 386857?Mouse
  • Unigene: 36585?Rat
    		•
    Synonyms:
  • F box only protein 11 Antibody
  • F box protein 11 Antibody
  • F-box only protein 11 Antibody
  • FBX11 Antibody
  • FBX11_HUMAN Antibody
  • FBXO11 Antibody
  • PRMT9 Antibody
  • Protein arginine N methyltransferase 9 Antibody
  • Ubiquitin protein ligase E3 component n recognin 6 Antibody
  • UBR6 Antibody
  • UG063H01 Antibody
  • VIT 1 Antibody
  • VIT-1 Antibody
  • VIT1 Antibody
  • Vitiligo associated protein 1 Antibody
  • Vitiligo associated protein VIT 1 Antibody
  • Vitiligo-associated protein 1 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
    产品留言
    标题
    联系人
    联系电话
    内容
    验证码
    点击换一张
    注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
    2.如有必要,请您留下您的详细联系方式!

    沪公网安备 31011202007337号