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Anti-FBXL5 Antibody

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产品名称: Anti-FBXL5 Antibody
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简单介绍

Anti-FBXL5 Antibody


Anti-FBXL5 Antibody  的详细介绍
Name: Anti-FBXL5 Antibody
See all FBXL5 primary antibodies
Description: Rabbit polyclonal antibody to FBXL5
Applications: ELISA, WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Rabbit polyclonal FBXL5 (1) antibody was raised against a recombinated human FBXL5 protein 510-691aa (BC030656).
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Affinity purified
Concentration: 1.0mg / ml
Formulation: PBS, pH 7.4 with 0.02% Sodium Azide
Storage: This product is stable for several weeks at 4?C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20?C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Function: Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued (By similarity).
Post-Translational Modification: Ubiquitinated upon iron and oxygen depletion, leading to its degradation by the proteasome. Ubiquitination is regulated by the hemerythrin-like region that acts as an oxygen and iron sensor (By similarity).
Cellular Location: Cytoplasm > Perinuclear region.
Database Links:
  • Entrez Gene: 26234?Human
  • Entrez Gene: 242960?Mouse
  • Entrez Gene: 305424?Rat
  • Omim: 605655?Human
  • SwissProt: Q9UKA1?Human
  • SwissProt: Q8C2S5?Mouse
  • Unigene: 643433?Human
  • Unigene: 714386?Human
  • Unigene: 25794?Mouse
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    Synonyms:
  • F box and leucine rich repeat protein 5 Antibody
  • F box protein FBL5 Antibody
  • F box/LRR repeat protein 5 Antibody
  • F-box and leucine-rich repeat protein 5 Antibody
  • F-box protein FBL4/FBL5 Antibody
  • F-box/LRR-repeat protein 5 Antibody
  • FBL4 Antibody
  • FBL5 Antibody
  • FBXL5 Antibody
  • FBXL5_HUMAN Antibody
  • FLR1 Antibody
  • p45SKP2 like protein Antibody
  • p45SKP2-like protein Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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