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Anti-FBXL3 Antibody

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产品名称: Anti-FBXL3 Antibody
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简单介绍

Anti-FBXL3 Antibody


Anti-FBXL3 Antibody  的详细介绍
Name: Anti-FBXL3 Antibody
See all FBXL3 primary antibodies
Description: Rabbit polyclonal antibody to FBXL3
Applications: WB, IF
Reactivity: Human
Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 14 and 279 of FBXL3
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Purified by antigen-affinity chromatography.
Formulation: Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
Storage: Store at -20˚C for long term preservation (recommended). Store at 4˚C for short term use.
Function: Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation (PubMed:17463251, PubMed:23452855, PubMed:27565346). The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2 (PubMed:17463251, PubMed:23452855, PubMed:27565346). Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex (PubMed:23452855).
Tissue Specificity: Widely expressed.
Cellular Location: Nucleus. Cytoplasm.

Predominantly nuclear.
Database Links:
  • Entrez Gene: 26224 Human
  • Omim: 605653 Human
  • SwissProt: Q9UKT7 Human
  • Unigene: 508284 Human
    		•
    Synonyms:
  • F box and leucine rich repeat protein 3 Antibody
  • F box and leucine rich repeat protein 3A Antibody
  • F box protein Fbl3a Antibody
  • F-box and leucine-rich repeat protein 3A Antibody
  • F-box/LRR-repeat protein 3 Antibody
  • F-box/LRR-repeat protein 3A Antibody
  • FBL3 Antibody
  • FBL3A Antibody
  • FBXL3 Antibody
  • FBXL3A Antibody
  • FBXL3_HUMAN Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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