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Anti-FBP1 Antibody

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产品名称: Anti-FBP1 Antibody
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简单介绍

Anti-FBP1 Antibody


Anti-FBP1 Antibody  的详细介绍
Name: Anti-FBP1 Antibody
See all FBP1 primary antibodies
Description: Rabbit polyclonal antibody to FBP1
Specificity: FBP1 pAb detects endogenous levels of FBP1 protein.
Applications: WB, IHC, IF
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant full length Human FBP1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~37 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.
Function: Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.
Tissue Specificity: Expressed in pancreatic islets.
Involvement in Disease: Fructose-1,6-bisphosphatase deficiency: An autosomal recessive metabolic disorder characterized by impaired gluconeogenesis, and episodes of hypoglycemia and metabolic acidosis that can be lethal in newborn infants or young children.
Sequence Similarities: Belongs to the FBPase class 1 family.
Database Links:
  • Entrez Gene: 2203?Human
  • Entrez Gene: 14121?Mouse
  • Entrez Gene: 24362?Rat
  • Omim: 611570?Human
  • SwissProt: P09467?Human
  • SwissProt: Q9QXD6?Mouse
  • SwissProt: P19112?Rat
  • Unigene: 494496?Human
  • Unigene: 423078?Mouse
  • Unigene: 33703?Rat
    		•
    Synonyms:
  • 6-bisphosphatase 1 Antibody
  • 6-bisphosphate 1-phosphohydrolase 1 Antibody
  • D fructose 1 6 bisphosphate 1 phosphohydrolase 1 Antibody
  • D-fructose-1 Antibody
  • EC 3.1.3.11 Antibody
  • F16P1_HUMAN Antibody
  • FBP Antibody
  • FBP 1 Antibody
  • FBP1 Antibody
  • FBPase 1 Antibody
  • Fructose 1 6 bisphosphatase 1 Antibody
  • Fructose bisphosphatase 1 Antibody
  • Fructose-1 Antibody
  • Growth inhibiting protein 17 Antibody
  • Liver fructose bisphosphatase Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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