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Anti-FANCM Antibody

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产品名称: Anti-FANCM Antibody
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简单介绍

Anti-FANCM Antibody


Anti-FANCM Antibody  的详细介绍
Name: Anti-FANCM Antibody
See all FANCM primary antibodies
Description: Rabbit polyclonal antibody to FANCM.
Applications: WB, IF
Dilutions: WB: 1:500 - 1:2000, IF: 1:50 - 1:100.
Reactivity: Human
Immunogen: Recombinant protein of human FANCM.
Protein Length: 2048
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (PubMed:16116422). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116422, PubMed:19423727, PubMed:20347428, PubMed:20347429). In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (PubMed:20347428, PubMed:20347429). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX (PubMed:20347429). In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (PubMed:17289582). In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA (PubMed:16116434).
Sequence Similarities: Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.
Post-Translational Modification: Phosphorylated; hyperphosphorylated in response to genotoxic stress.
Cellular Location: Nucleus.
Database Links:
  • Entrez Gene: 57697 Human
  • Omim: 609644 Human
  • SwissProt: Q8IYD8 Human
  • Unigene: 509229 Human
    		•
    Synonyms:
  • ATP-dependent RNA helicase FANCM Antibody
  • FAAP250 Antibody
  • FANCM Antibody
  • Fanconi anemia group M protein Antibody
  • fanconi anemia-associated polypeptide of 250 kDa Antibody
  • KIAA1596 Antibody
  • Protein Hef ortholog Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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