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Anti-FANCD2 Antibody

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产品名称: Anti-FANCD2 Antibody
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简单介绍

Anti-FANCD2 Antibody


Anti-FANCD2 Antibody  的详细介绍
Name: Anti-FANCD2 Antibody
See all FANCD2 primary antibodies
Description: Rabbit polyclonal antibody to FANCD2
Specificity: The antibody detects endogenous level of total FANCD2 protein.
Applications: WB, IHC, IF
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human FANCD2.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antibodies were purified by affinity purification using immunogen.
Concentration: 1.0mg / ml
Formulation: Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20?C
Function: Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching.
Tissue Specificity: Highly expressed in germinal center cells of the spleen, tonsil, and reactive lymph nodes, and in the proliferating basal layer of squamous epithelium of tonsil, esophagus, oropharynx, larynx and cervix. Expressed in cytotrophoblastic cells of the placenta and exocrine cells of the pancreas (at protein level). Highly expressed in testis, where expression is restricted to maturing spermatocytes.
Involvement in Disease: Fanconi anemia complementation group D2: A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.
Post-Translational Modification: Monoubiquitinated on Lys-561 during S phase and upon genotoxic stress by FANCL in complex with E2 ligases UBE2T or UBE2W (isoform 1 and isoform 2). Deubiquitinated by USP1 as cells enter G2/M, or once DNA repair is completed. Monoubiquitination requires the joint intervention of the FANC core complex, including FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, and FANCM, and proteins involved in cell cycle checkpoints and DNA repair, including RPA1, ATR, CHEK1 and BRCA1, and is mediated by FANCL/PHF9. Ubiquitination is required for binding to chromatin, interaction with BRCA1, BRCA2 and MTMR15/FAN1, DNA repair, and normal cell cycle progression, but not for phosphorylation on Ser-222 or interaction with MEN1.
Cellular Location: Nucleus.

Concentrates in nuclear foci during S phase and upon genotoxic stress. At the onset of mitosis, excluded from chromosomes and diffuses into the cytoplasm, returning to the nucleus at the end of cell division. Observed in a few spots localized in pairs on the sister chromatids of mitotic chromosome arms and not centromeres, one on each chromatids. These foci coincide with common fragile sites and could be sites of replication fork stalling. The foci are frequently interlinked through BLM-associated ultra-fine DNA bridges. Following aphidicolin treatment, targets chromatid gaps and breaks.
Database Links:
  • Entrez Gene: 2177?Human
  • Entrez Gene: 211651?Mouse
  • Entrez Gene: 312641?Rat
  • Omim: 613984?Human
  • SwissProt: Q9BXW9?Human
  • SwissProt: Q80V62?Mouse
  • SwissProt: Q6IV68?Rat
  • Unigene: 208388?Human
  • Unigene: 160061?Mouse
  • Unigene: 203979?Rat
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    Synonyms:
  • DKFZp762A223 Antibody
  • FA 4 Antibody
  • FA D2 Antibody
  • FA4 Antibody
  • FAC D2 Antibody
  • FACD Antibody
  • FACD 2 Antibody
  • FACD2 Antibody
  • FACD2_HUMAN Antibody
  • FAD Antibody
  • FAD2 Antibody
  • FANC D2 Antibody
  • FANCD Antibody
  • FANCD 2 Antibody
  • FANCD2 Antibody
  • FANCONI ANEMIA COMPLEMENTATION GROUP D Antibody
  • Fanconi anemia complementation group D2 Antibody
  • Fanconi anemia group D2 protein Antibody
  • FANCONI PANCYTOPENIA TYPE 4 Antibody
  • FLJ23826 Antibody
  • OTTHUMP00000158853 Antibody
  • OTTHUMP00000207925 Antibody
  • Protein FACD2 Antibody
  • Type 4 Fanconi pancytopenia Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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