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Anti-FANCC Antibody

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产品名称: Anti-FANCC Antibody
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简单介绍

Anti-FANCC Antibody


Anti-FANCC Antibody  的详细介绍
Name: Anti-FANCC Antibody
See all FANCC primary antibodies
Description: Rabbit polyclonal antibody to FANCC
Specificity: The antibody detects endogenous level of total FANCC protein.
Applications: WB, IHC, IF
Reactivity: Human
Immunogen: Recombinant protein of human FANCC.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antibodies were purified by affinity purification using immunogen.
Concentration: 1.0mg / ml
Formulation: Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20?C
Function: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.
Tissue Specificity: Ubiquitous.
Involvement in Disease: Fanconi anemia complementation group C: A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.
Cellular Location: Nucleus. Cytoplasm.

The major form is nuclear. The minor form is cytoplasmic.
Database Links:
  • Entrez Gene: 2176?Human
  • Omim: 613899?Human
  • SwissProt: Q00597?Human
  • Unigene: 494529?Human
    		•
    Synonyms:
  • bA80I15.1 Antibody
  • FA 3 Antibody
  • FA3 Antibody
  • FAC Antibody
  • FACC Antibody
  • FANCC Antibody
  • FANCC_HUMAN Antibody
  • Fanconi anemia complementation group C Antibody
  • Fanconi anemia complementation group C protein Antibody
  • Fanconi anemia group C protein Antibody
  • Fanconi pancytopenia type 3 Antibody
  • FLJ14675 Antibody
  • Protein FACC Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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