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Anti-FANCA (phospho-S1149) Antibody

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产品名称: Anti-FANCA (phospho-S1149) Antibody
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Anti-FANCA (phospho-S1149) Antibody


Anti-FANCA (phospho-S1149) Antibody  的详细介绍
Name: Anti-FANCA (phospho-S1149) Antibody
See all FANCA primary antibodies
Description: Rabbit polyclonal antibody to FANCA (phospho-S1149)
Specificity: p-FANCA (S1149) pAb detects endogenous levels of FANCA protein only when phosphorylated at Ser1149.
Applications: WB, IHC, ICC, IP
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic phosphopeptide derived from human FANCA around the phosphorylation site of Serine 1149.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 163 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability.
Involvement in Disease: Fanconi anemia, complementation group A: A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.
Post-Translational Modification: Phosphorylation is required for the formation of the nuclear complex. Not phosphorylated in cells derived from groups A, B, C, E, F, G, and H.
Cellular Location: Nucleus. Cytoplasm.

The major form is nuclear. The minor form is cytoplasmic.
Database Links:
  • Entrez Gene: 2175?Human
  • Entrez Gene: 14087?Mouse
  • Omim: 607139?Human
  • SwissProt: O15360?Human
  • SwissProt: Q9JL70?Mouse
  • Unigene: 290154?Human
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    Synonyms:
  • FA Antibody
  • FA 1 Antibody
  • FA H Antibody
  • FA1 Antibody
  • FAA Antibody
  • FACA Antibody
  • FAH Antibody
  • FANCA Antibody
  • FANCA_HUMAN Antibody
  • FANCH Antibody
  • Fanconi anemia complementation group A Antibody
  • Fanconi anemia complementation group H Antibody
  • Fanconi anemia group A protein Antibody
  • Fanconi anemia type 1 Antibody
  • MGC75158 Antibody
  • Protein FACA Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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