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Antibodies
Anti-FAK1 Antibody
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产品名称:
Anti-FAK1 Antibody
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简单介绍
Anti-FAK1
Antibody
Anti-FAK1 Antibody
的详细介绍
Overview
Name:
Anti-FAK1
Antibody
See all FAK1 primary antibodies
Description:
Chicken polyclonal antibody to FAK1
Applications:
ELISA, IHC, IP, WB
Dilutions:
ELISA: 1:10,000; ELISA: 1:10,000; Immunocytochemistry: 1:100; Immunofluorescence: 1:100; Immunohistochemistry: 1:100; Immunoprecipitation: 1:200; Western Blot: 1:500
Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide taken within amino acid region 740-790 on human focal adhesion kinase 1 protein.
Host:
Chicken
Clonality:
Polyclonal
Conjugate:
Unconjugated
Concentration:
0.6 μg/μl in antibody stabilization buffer
Storage:
-20?C for long term storage
Target
Background:
Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating s for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription.
Database Links:
Entrez Gene: 5747?Human
Entrez Gene: 14083?Mouse
Entrez Gene: 25614?Rat
Omim: 600758?Human
SwissProt: Q05397?Human
SwissProt: P34152?Mouse
SwissProt: O35346?Rat
Unigene: 395482?Human
Unigene: 254494?Mouse
Unigene: 2809?Rat
Synonyms:
FADK Antibody
FADK 1 Antibody
FAK Antibody
FAK related non kinase polypeptide Antibody
FAK1 Antibody
FAK1_HUMAN Antibody
Focal adhesion Kinase Antibody
Focal adhesion kinase 1 Antibody
Focal adhesion kinase isoform FAK Del33 Antibody
Focal adhesion kinase related nonkinase Antibody
FRNK Antibody
p125FAK Antibody
pp125FAK Antibody
PPP1R71 Antibody
Protein phosphatase 1 regulatory subunit 71 Antibody
Protein tyrosine kinase 2 Antibody
Protein-tyrosine kinase 2 Antibody
Ptk2 Antibody
PTK2 protein tyrosine kinase 2 Antibody
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