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Antibodies
Anti-FADD Antibody
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产品名称:
Anti-FADD Antibody
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简单介绍
Anti-FADD
Antibody
Anti-FADD Antibody
的详细介绍
Overview
Name:
Anti-FADD
Antibody
See all FADD primary antibodies
Description:
Rabbit polyclonal antibody to FADD.
Applications:
WB, IHC
Dilutions:
WB: 1:500 - 1:2000, IHC: 1:50 - 1:200.
Reactivity:
Human, Mouse, Rat
Immunogen:
Recombinant protein of human FADD.
Protein Length:
208
Host:
Rabbit
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Unconjugated
Purification:
Affinity purification.
Product Form:
Liquid
Formulation:
Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Target
Function:
Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.
Tissue Specificity:
Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes.
Involvement in Disease:
Infections, recurrent, associated with encephalopathy, hepatic dysfunction and cardiovascular malformations: A condition with
biolog
ical features of autoimmune lymphoproliferative syndrome such as high-circulating CD4(-)CD8(-)TCR-alpha-beta(+) T-cell counts, and elevated IL10 and FASL levels. Affected individuals suffer from recurrent, stereotypical episodes of fever, encephalopathy, and mild liver dysfunction sometimes accompanied by generalized seizures. The episodes can be triggered by varicella zoster virus (VZV), measles mumps rubella (MMR) attenuated vaccine, parainfluenza virus, and Epstein-Barr virus (EBV).
Database Links:
Entrez Gene: 8772?Human
Entrez Gene: 14082?Mouse
Entrez Gene: 266610?Rat
Omim: 602457?Human
SwissProt: Q13158?Human
SwissProt: Q61160?Mouse
Unigene: 86131?Human
Unigene: 5126?Mouse
Unigene: 16183?Rat
Synonyms:
FADD Antibody
FADD protein Antibody
FADD_HUMAN Antibody
Fas (TNFRSF6) associated via death domain Antibody
Fas associated via death domain Antibody
Fas associating death domain containing protein Antibody
Fas associating protein Antibody
Fas associating protein with death domain Antibody
Fas TNFRSF6 associated via death domain Antibody
FAS-associated death domain protein Antibody
FAS-associating death domain-containing protein Antibody
GIG 3 Antibody
GIG3 Antibody
Growth inhibiting gene 3 protein Antibody
Growth-inhibiting gene 3 protein Antibody
H sapiens mRNA for mediator of receptor induced toxicity Antibody
Mediator of receptor induced toxicity Antibody
MGC8528 Antibody
MORT 1 Antibody
MORT1 Antibody
Protein FADD Antibody
Information:
Target information shown above is from the UniProt Consortium.
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