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Anti-Factor XI Antibody

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产品名称: Anti-Factor XI Antibody
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简单介绍

Anti-Factor XI Antibody


Anti-Factor XI Antibody  的详细介绍
Name: Anti-Factor XI Antibody
See all Factor XI primary antibodies
Description: Rabbit polyclonal antibody to Factor XI
Applications: WB, IHC
Reactivity: Human
Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 282 of Human F11
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Purified by antigen-affinity chromatography.
Formulation: Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
Storage: Store at -20?C for long term preservation (recommended). Store at 4?C for short term use.
Function: Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
Tissue Specificity: Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells.
Involvement in Disease: Factor XI deficiency: A hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate.
Sequence Similarities: Belongs to the peptidase S1 family. Plasma kallikrein subfamily.
Post-Translational Modification: N-glycosylated on both chains. N-glycosylated sites mainly consist of nonfucosylated sialylated biantennary (in high abundance) and/or triantennary (in low abundance) complex structures. Glycosylation at Asn-163 uses a rare non-canonical Asn-X-Cys glycosite.
Cellular Location: Secreted.
Database Links:
  • Entrez Gene: 2160?Human
  • Omim: 264900?Human
  • SwissProt: P03951?Human
  • Unigene: 1430?Human
    		•
    Synonyms:
  • Coagulation factor XI Antibody
  • Coagulation factor XIa light chain Antibody
  • F11 Antibody
  • FA11_HUMAN Antibody
  • Factor XI Antibody
  • FXI Antibody
  • MGC141891 Antibody
  • Plasma thromboplastin antecedent Antibody
  • PTA Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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