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Anti-Ezrin (Phospho-Thr567) Antibody

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产品名称: Anti-Ezrin (Phospho-Thr567) Antibody
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Anti-Ezrin (Phospho-Thr567) Antibody


Anti-Ezrin (Phospho-Thr567) Antibody  的详细介绍
Name: Anti-Ezrin (Phospho-Thr567) Antibody
See all Ezrin primary antibodies
Description: Rabbit polyclonal antibody to Ezrin (Phospho-Thr567)
Specificity: The antibody detects endogenous level of Ezrin only when phosphorylated at threonine 567.
Applications: WB
Reactivity: Human, Mouse, Rat
Immunogen: Peptide sequence around phosphorylation site of threonine 567 (Y-K-T(p)-L-R) derived from Human Ezrin.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration: 1.0mg / ml
Formulation: Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Function: Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis.
Tissue Specificity: Expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. Weakly expressed in brain stem and diencephalon. Stronger expression was detected in gray matter of frontal lobe compared to white matter (at protein level). Component of the microvilli of intestinal epithelial cells. Preferentially expressed in astrocytes of hippocampus, frontal cortex, thalamus, parahippocampal cortex, amygdala, insula, and corpus callosum. Not detected in neurons in most tissues studied.
Post-Translational Modification: Phosphorylated by tyrosine-protein kinases. Phosphorylation by ROCK2 suppresses the head-to-tail association of the N-terminal and C-terminal halves resulting in an opened conformation which is capable of actin and membrane-binding (By similarity).
Cellular Location: Apical cell membrane. Cell projection. Cell projection > Microvillus membrane. Cell projection > Ruffle membrane. Cytoplasm > Cell cortex. Cytoplasm > Cytoskeleton.

Localization to the apical membrane of parietal cells depends on the interaction with MPP5. Localizes to cell extensions and peripheral processes of astrocytes (By similarity). Microvillar peripheral membrane protein (cytoplasmic side).
Database Links:
  • Entrez Gene: 7430 Human
  • Entrez Gene: 22350 Mouse
  • Entrez Gene: 54319 Rat
  • Omim: 123900 Human
  • SwissProt: P15311 Human
  • SwissProt: P26040 Mouse
  • SwissProt: P31977 Rat
  • Unigene: 487027 Human
  • Unigene: 277812 Mouse
  • Unigene: 773 Rat
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    Synonyms:
  • Villin 2 ezrin Antibody
  • CVIL Antibody
  • CVL Antibody
  • Cytovillin Antibody
  • Cytovillin 2 Antibody
  • DKFZp762H157 Antibody
  • Epididymis secretory protein Li 105 Antibody
  • EZR Antibody
  • Ezrin Antibody
  • EZRI_HUMAN Antibody
  • FLJ26216 Antibody
  • HEL S 105 Antibody
  • MGC1584 Antibody
  • p81 Antibody
  • VIL 2 Antibody
  • VIL2 Antibody
  • Villin 2 Antibody
  • Villin 2 (ezrin) Antibody
  • Villin-2 Antibody
  • Villin2 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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