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Anti-EZH1 Antibody

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产品名称: Anti-EZH1 Antibody
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简单介绍

Anti-EZH1 Antibody


Anti-EZH1 Antibody  的详细介绍
Name: Anti-EZH1 Antibody
See all EZH1 primary antibodies
Description: Goat polyclonal antibody to EZH1.
Applications: ELISA, WB
Reactivity: Human
Immunogen: Synthetic peptide corresponding to Human EZH1 (N terminal).
Sequence: EIPNPPTSKCITY
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 µg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.
Sequence Similarities: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily.
Cellular Location: Nucleus.

Colocalizes with trimethylated 'Lys-27' of histone H3.
Database Links:
  • Entrez Gene: 2145 Human
  • Omim: 601674 Human
  • SwissProt: Q92800 Human
  • Unigene: 194669 Human
    		•
    Synonyms:
  • Enhancer of zeste homolog 1 Antibody
  • Enhancer of zeste homolog 1 (Drosophila) Antibody
  • ENX-2 Antibody
  • ENX2 Antibody
  • EZH1 Antibody
  • EZH1_HUMAN Antibody
  • Histone-lysine N-methyltransferase EZH1 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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