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Antibodies
Anti-EYA4 Antibody
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产品名称:
Anti-EYA4 Antibody
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简单介绍
Anti-EYA4
Antibody
Anti-EYA4 Antibody
的详细介绍
Overview
Name:
Anti-EYA4
Antibody
See all EYA4 primary antibodies
Description:
Goat polyclonal antibody to EYA4.
Applications:
ELISA, IHC
Reactivity:
Human
Immunogen:
Synthetic peptide corresponding to Human EYA4 (N terminal).
Sequence:
EDSQDLNEQSVKKTC
Host:
Goat
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Unconjugated
Purification:
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:
100 μg at 0.5 mg/ml.
Product Form:
Liquid
Formulation:
Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Target
Function:
Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity).
Tissue Specificity:
Highly expressed in heart and skeletal muscle.
Involvement in Disease:
Deafness, autosomal dominant, 10: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Cardiomyopathy, dilated 1J: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. CMD1J is characterized by the association of sensorineural hearing loss and dilated cardiomyopathy in the absence of other anomalies.
Sequence Similarities:
Belongs to the HAD-like hydrolase superfamily. EYA family.
Cellular Location:
Cytoplasm. Nucleus.
Database Links:
Entrez Gene: 2070?Human
Omim: 603550?Human
SwissProt: O95677?Human
Unigene: 596680?Human
Synonyms:
CMD1J Antibody
Deafness, autosomal dominant 10 Antibody
DFNA 10 Antibody
DFNA10 Antibody
dJ78N10.1 (eyes absent (Drosophila) homolog 4) Antibody
dJ78N10.1 (eyes absent) Antibody
EYA 4 Antibody
EYA4 Antibody
EYA4_HUMAN Antibody
Eyes absent 4 Antibody
Eyes absent homolog 4 Antibody
Eyes absent homolog 4 (Drosophila) Antibody
HGNC:3522 Antibody
OTTHUMP00000040267 Antibody
Information:
Target information shown above is from the UniProt Consortium.
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