首页
品牌
ELISA试剂盒
抗体抗原
公司新闻
技术文章
关于拜力
留言询价
产品资料
首页
>>>
产品目录
>>>
中国授权代理品牌
>>> 
Antibodies
Anti-EYA1 Antibody
点击看大图
如果您对该产品感兴趣的话,可以
产品名称:
Anti-EYA1 Antibody
产品型号:
产品展商:
其它品牌
产品文档:
无相关文档
简单介绍
Anti-EYA1
Antibody
Anti-EYA1 Antibody
的详细介绍
Overview
Name:
Anti-EYA1
Antibody
See all EYA1 primary antibodies
Description:
Goat polyclonal antibody to EYA1.
Applications:
ELISA, WB
Reactivity:
Human
Immunogen:
Synthetic peptide corresponding to Human EYA1 (internal region).
Sequence:
C-TDPTAEYSTIHSP
Host:
Goat
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Unconjugated
Purification:
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:
100 µg at 0.5 mg/ml.
Product Form:
Liquid
Formulation:
Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Target
Function:
Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (By similarity). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19234442). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis (By similarity). Has also phosphatase activity with proteins phosphorylated on Ser and Thr residues (in vitro) (By similarity). Required for normal embryonic development of the craniofacial and trunk skeleton, kidneys and ears (By similarity). Together with SIX1, it plays an important role in hypaxial muscle development; in this it is functionally redundant with EYA2 (By similarity).
Tissue Specificity:
In the embryo, highly expressed in kidney with lower levels in brain. Weakly expressed in lung. In the *****, highly expressed in heart and skeletal muscle. Weakly expressed in brain and liver. No expression in eye or kidney.
Involvement in Disease:
Branchiootorenal syndrome 1: A syndrome characterized by branchial cleft fistulas or cysts, sensorineural and/or conductive hearing loss, pre-auricular pits, structural defects of the outer, middle or inner ear, and renal malformations.
Otofaciocervical syndrome 1: A disorder characterized by facial dysmorphism, cup-shaped low-set ears, preauricular fistulas, hearing loss, branchial defects, skeletal anomalies including vertebral defects, low-set clavicles, winged scapulae, sloping shoulders, and mild intellectual disability.
Branchiootic syndrome 1: A syndrome characterized by usually bilateral branchial cleft fistulas or cysts, sensorineural and/or conductive hearing loss, pre-auricular pits, and structural defects of the outer, middle or inner ear. Otic defects include malformed and hypoplastic pinnae, a narrowed external ear canal, bulbous internal auditory canal, stapes fixation, malformed and hypoplastic cochlea. Branchial and otic anomalies overlap with those seen in individuals with the branchiootorenal syndrome. However renal anomalies are absent in branchiootic syndrome patients.
Anterior segment anomalies with or without cataract: A disease characterized by various types of developmental eye anomalies, in the absence of other abnormalities. The phenotypic spectrum of anterior segment anomalies include central corneal opacity, Peters anomaly, and bilateral persistence of the pupillary membrane. Some patients have cataract.
Sequence Similarities:
Belongs to the HAD-like hydrolase superfamily. EYA family.
Post-Translational Modification:
Sumoylated with SUMO1.
Cellular Location:
Cytoplasm. Nucleus.
Localizes at sites of DNA damage at double-strand breaks (DSBs).
Database Links:
Entrez Gene: 2138 Human
Omim: 601653 Human
SwissProt: Q99502 Human
Unigene: 491997 Human
Synonyms:
BOP Antibody
BOR Antibody
BOS1 Antibody
EYA transcriptional coactivator and phosphatase 1 Antibody
EYA1 Antibody
EYA1_HUMAN Antibody
Eyes absent 1 Antibody
Eyes absent 1 homolog Antibody
Eyes absent homolog 1 Antibody
Eyes absent homolog 1 (Drosophila) Antibody
Eyes absent homolog1 Antibody
MGC141875 Antibody
OFC1 Antibody
Information:
Target information shown above is from the UniProt Consortium.
产品留言
标题
联系人
联系电话
内容
验证码
点击换一张
注:1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!
相关产品
Anti-Fer Antibody
Anti-FER (Phospho-Tyr402) Antibody
Anti-FEN1 Antibody
Anti-FEN1 Antibody
Anti-FEN1 (A119) Antibody
Anti-FEN1 (7H8) Antibody
Anti-FEN-1 Antibody
Anti-FEM1B Antibody
Anti-FEM1A Antibody
Anti-FEM1A Antibody
Anti-FDXR Antibody
Anti-FDPS Antibody
Anti-FDPS Antibody
Anti-FDFT1 Antibody
Anti-FDFT1 Antibody
Anti-FDCSP Antibody
Anti-FCRL4 Antibody
Anti-FCHO1 Antibody
Anti-FCGR3A Antibody
Anti-FCGR2B Antibody
Anti-FCGR2A Antibody
Anti-FCGR2A Antibody
Anti-FCER2 Antibody
Anti-FCER1A Antibody
Anti-FCAR Antibody
Anti-FBXW7 Antibody
Anti-FBXW4 Antibody
Anti-FBXW12 Antibody
Anti-FBXO44 Antibody
Anti-FBXO44 Antibody
Copyright@ 2003-2024
上海拜力生物科技有限公司
版权所有
本公司网站所展示销售的产品仅供科研!
沪ICP备08023583号-12
沪公网安备 31011202007337号