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Anti-ESX1 Antibody

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产品名称: Anti-ESX1 Antibody
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简单介绍

Anti-ESX1 Antibody


Anti-ESX1 Antibody  的详细介绍
Name: Anti-ESX1 Antibody
See all ESX1 primary antibodies
Description: Rabbit polyclonal antibody to ESX1
Applications: E, WB, IHC
Reactivity: Human
Immunogen: Raised against a 19 amino acid peptide near the center of human ESX1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Affinity chromatography purified via peptide column
Formulation: Supplied in PBS containing 0.02% sodium azide.
Storage: Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Function: May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover.
Tissue Specificity: Expressed in placenta and testis. Expressed in testicular germ cell tumors.
Post-Translational Modification: Undergoes proteolytic cleavage; produces a 45 kDa N-terminal homeodomain-containing fragment (ESXR1-N) and a 20 kDa C-terminal fragment (ESXR1-C).
Cellular Location: Cytoplasm. Nucleus.

ESXR1-N localizes specifically to the nucleus while ESXR1-C localizes specifically to the cytoplasm.
Database Links:
  • Entrez Gene: 80712?Human
  • Omim: 300154?Human
  • SwissProt: Q8N693?Human
  • Unigene: 223782?Human
    		•
    Synonyms:
  • Epx Antibody
  • ESX1 Antibody
  • ESX1L Antibody
  • ESX1_HUMAN Antibody
  • ESXR1 Antibody
  • Etx Antibody
  • Extraembryonic Antibody
  • Extraembryonic spermatogenesis homeobox 1 Antibody
  • homeobox 1 Antibody
  • Homeobox protein ESX1-C Antibody
  • spermatogenesis Antibody
  • Spx1 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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