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Anti-ERK1/2 Antibody

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产品名称: Anti-ERK1/2 Antibody
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Anti-ERK1/2 Antibody


Anti-ERK1/2 Antibody  的详细介绍
Name: Anti-ERK1/2 Antibody
See all ERK1 primary antibodies
Description: Mouse monoclonal antibody to ERK1/2
Specificity: This antibody detects endogenous levels of ERK1/2 and does not cross-react with related proteins
Applications: WB
Reactivity: Human, Mouse
Immunogen: Recombinant full length Human ERK1.
Host: Mouse
Clonality: Monoclonal
Conjugate: Unconjugated
Molecular Weight: Predicted band size:42/44KDa Observed band size:42/44KDa
Purity: The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade.
Sequence Similarities: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Post-Translational Modification: Phosphorylated upon KIT and FLT3 signaling (By similarity). Dually phosphorylated on Thr-202 and Tyr-204, which activates the enzyme. Ligand-activated ALK induces tyrosine phosphorylation. Dephosphorylated by PTPRJ at Tyr-204.
Cellular Location: Cytoplasm. Nucleus.

Autophosphorylation at Thr-207 promotes nuclear localization.
Database Links:
  • Entrez Gene: 5595 Human
  • Entrez Gene: 26417 Mouse
  • Omim: 601795 Human
  • SwissProt: P27361 Human
  • SwissProt: Q63844 Mouse
  • Unigene: 861 Human
  • Unigene: 8385 Mouse
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    Synonyms:
  • ERK Antibody
  • ERK 1 Antibody
  • ERK-1 Antibody
  • ERK1 Antibody
  • ERT 2 Antibody
  • ERT2 Antibody
  • Extracellular Signal Regulated Kinase 1 Antibody
  • Extracellular signal related kinase Antibody
  • Extracellular signal related kinase 1 Antibody
  • Extracellular signal-regulated kinase 1 Antibody
  • HGNC6877 Antibody
  • HS44KDAP Antibody
  • HUMKER1A Antibody
  • Insulin Stimulated MAP2 Kinase Antibody
  • Insulin-stimulated MAP2 kinase Antibody
  • MAP Kinase Antibody
  • MAP kinase 1 Antibody
  • MAP kinase 3 Antibody
  • MAP kinase isoform p44 Antibody
  • MAPK Antibody
  • MAPK 1 Antibody
  • MAPK 3 Antibody
  • MAPK1 Antibody
  • Mapk3 Antibody
  • MGC20180 Antibody
  • Microtubule Associated Protein 2 Kinase Antibody
  • Microtubule-associated protein 2 kinase Antibody
  • Mitogen Activated Protein Kinase 3 Antibody
  • Mitogen-activated protein kinase 1 Antibody
  • Mitogen-activated protein kinase 3 Antibody
  • MK03_HUMAN Antibody
  • OTTHUMP00000174538 Antibody
  • OTTHUMP00000174541 Antibody
  • p44 ERK1 Antibody
  • p44 MAPK Antibody
  • p44-ERK1 Antibody
  • p44-MAPK Antibody
  • P44ERK1 Antibody
  • P44MAPK Antibody
  • PRKM 3 Antibody
  • PRKM3 Antibody
  • Protein Kinase Mitogen Activated 3 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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