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Antibodies
Anti-ErbB2/HER2 (K676) Antibody
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产品名称:
Anti-ErbB2/HER2 (K676) Antibody
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简单介绍
Anti-ErbB2/HER2 (K676)
Antibody
Anti-ErbB2/HER2 (K676) Antibody
的详细介绍
Overview
Name:
Anti-ErbB2/HER2 (K676)
Antibody
See all ErbB2 primary antibodies
Description:
Rabbit polyclonal antibody to ErbB2/HER2 (K676)
Specificity:
ErbB2/HER2 (K676) pAb detects endogenous levels of ErbB2/HER2 protein.
Applications:
WB, IHC, IF
Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide, corresponding to amino acids 641-690 of Human ErbB2/HER2.
Host:
Rabbit
Clonality:
Polyclonal
Conjugate:
Unconjugated
Molecular Weight:
~ 138,185 kDa
Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Target
Function:
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
Tissue Specificity:
Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.
Involvement in Disease:
Hereditary diffuse gastric cancer: A cancer predisposition syndrome with increased susceptibility to diffuse gastric cancer. Diffuse gastric cancer is a malignant disease characterized by poorly differentiated infiltrating lesions resulting in thickening of the stomach. Malignant tumors start in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body.
Glioma: Gliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes.
Ovarian cancer: The term ovarian cancer defines malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease.
Lung cancer: A common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis.
Gastric cancer: A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease.
Sequence Similarities:
Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
Post-Translational Modification:
Autophosphorylated. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit (Probable). Ligand-binding increases phosphorylation on tyrosine residues (PubMed:27134172). Signaling via SEMA4C promotes phosphorylation at Tyr-1248 (PubMed:17554007). Dephosphorylated by PTPN12 (PubMed:27134172).
Cellular Location:
Cell membrane. Cytoplasm > Perinuclear region. Nucleus.
Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1.
Database Links:
Entrez Gene: 2064?Human
Entrez Gene: 13866?Mouse
Entrez Gene: 24337?Rat
Omim: 164870?Human
SwissProt: P04626?Human
SwissProt: P70424?Mouse
SwissProt: P06494?Rat
Unigene: 446352?Human
Unigene: 290822?Mouse
Unigene: 93966?Rat
Synonyms:
Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog Antibody
C erb B2/neu protein Antibody
CD340 Antibody
CD340 antigen Antibody
Cerb B2/neu protein Antibody
CerbB2 Antibody
Erb b2 receptor tyrosine kinase 2 Antibody
ErbB 2 Antibody
ERBB2 Antibody
ERBB2_HUMAN Antibody
HER 2 Antibody
HER 2/NEU Antibody
HER2 Antibody
Herstatin Antibody
Human epidermal growth factor receptor 2 Antibody
Metastatic lymph node gene 19 protein Antibody
MLN 19 Antibody
MLN19 Antibody
NEU Antibody
NEU proto oncogene Antibody
Neuro/glioblastoma derived oncogene homolog Antibody
Neuroblastoma/glioblastoma derived oncogene homolog Antibody
NGL Antibody
p185erbB2 Antibody
Proto-oncogene c-ErbB-2 Antibody
Proto-oncogene Neu Antibody
Receptor tyrosine-protein kinase erbB-2 Antibody
TKR1 Antibody
Tyrosine kinase type cell surface receptor HER2 Antibody
Tyrosine kinase-type cell surface receptor HER2 Antibody
V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 Antibody
V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog) Antibody
V erb b2 avian erythroblastic leukemia viral oncoprotein 2 Antibody
V erb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog Antibody
V erb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) Antibody
Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) Antibody
Information:
Target information shown above is from the UniProt Consortium.
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