产品资料

Anti-ErbB2/HER2 (D871) Antibody

如果您对该产品感兴趣的话,可以
产品名称: Anti-ErbB2/HER2 (D871) Antibody
产品型号:
产品展商: 其它品牌
产品文档: 无相关文档

简单介绍

Anti-ErbB2/HER2 (D871) Antibody


Anti-ErbB2/HER2 (D871) Antibody  的详细介绍
Name: Anti-ErbB2/HER2 (D871) Antibody
See all ErbB2 primary antibodies
Description: Rabbit polyclonal antibody to ErbB2/HER2 (D871)
Specificity: ErbB2/HER2 (D871) pAb detects endogenous levels of ErbB2/HER2 protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 841-890 of Human ErbB2/HER2.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 138,185 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
Tissue Specificity: Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.
Involvement in Disease: Hereditary diffuse gastric cancer: A cancer predisposition syndrome with increased susceptibility to diffuse gastric cancer. Diffuse gastric cancer is a malignant disease characterized by poorly differentiated infiltrating lesions resulting in thickening of the stomach. Malignant tumors start in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body.

Glioma: Gliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes.

Ovarian cancer: The term ovarian cancer defines malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease.

Lung cancer: A common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis.

Gastric cancer: A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease.
Sequence Similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
Post-Translational Modification: Autophosphorylated. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit (Probable). Ligand-binding increases phosphorylation on tyrosine residues (PubMed:27134172). Signaling via SEMA4C promotes phosphorylation at Tyr-1248 (PubMed:17554007). Dephosphorylated by PTPN12 (PubMed:27134172).
Cellular Location: Cell membrane. Cytoplasm > Perinuclear region. Nucleus.

Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1.
Database Links:
  • Entrez Gene: 2064?Human
  • Entrez Gene: 13866?Mouse
  • Entrez Gene: 24337?Rat
  • Omim: 164870?Human
  • SwissProt: P04626?Human
  • SwissProt: P70424?Mouse
  • SwissProt: P06494?Rat
  • Unigene: 446352?Human
  • Unigene: 290822?Mouse
  • Unigene: 93966?Rat
    		•
    Synonyms:
  • Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog Antibody
  • C erb B2/neu protein Antibody
  • CD340 Antibody
  • CD340 antigen Antibody
  • Cerb B2/neu protein Antibody
  • CerbB2 Antibody
  • Erb b2 receptor tyrosine kinase 2 Antibody
  • ErbB 2 Antibody
  • ERBB2 Antibody
  • ERBB2_HUMAN Antibody
  • HER 2 Antibody
  • HER 2/NEU Antibody
  • HER2 Antibody
  • Herstatin Antibody
  • Human epidermal growth factor receptor 2 Antibody
  • Metastatic lymph node gene 19 protein Antibody
  • MLN 19 Antibody
  • MLN19 Antibody
  • NEU Antibody
  • NEU proto oncogene Antibody
  • Neuro/glioblastoma derived oncogene homolog Antibody
  • Neuroblastoma/glioblastoma derived oncogene homolog Antibody
  • NGL Antibody
  • p185erbB2 Antibody
  • Proto-oncogene c-ErbB-2 Antibody
  • Proto-oncogene Neu Antibody
  • Receptor tyrosine-protein kinase erbB-2 Antibody
  • TKR1 Antibody
  • Tyrosine kinase type cell surface receptor HER2 Antibody
  • Tyrosine kinase-type cell surface receptor HER2 Antibody
  • V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 Antibody
  • V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog) Antibody
  • V erb b2 avian erythroblastic leukemia viral oncoprotein 2 Antibody
  • V erb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog Antibody
  • V erb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) Antibody
  • Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
    产品留言
    标题
    联系人
    联系电话
    内容
    验证码
    点击换一张
    注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
    2.如有必要,请您留下您的详细联系方式!

    沪公网安备 31011202007337号