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Anti-ErbB-3 (E1218) Antibody

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产品名称: Anti-ErbB-3 (E1218) Antibody
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Anti-ErbB-3 (E1218) Antibody


Anti-ErbB-3 (E1218) Antibody  的详细介绍
Name: Anti-ErbB-3 (E1218) Antibody
See all ErbB3 primary antibodies
Description: Rabbit polyclonal antibody to ErbB-3 (E1218)
Specificity: ErbB-3 (E1218) pAb detects endogenous levels of ErbB-3 protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 1200-1250 of Human ErbB-3.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 148, 185 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134).
Tissue Specificity: Epithelial tissues and brain.
Involvement in Disease: Lethal congenital contracture syndrome 2: A form of lethal congenital contracture syndrome, an autosomal recessive disorder characterized by degeneration of anterior horn neurons, extreme skeletal muscle atrophy, and congenital non-progressive joint contractures (arthrogryposis). The contractures can involve the upper or lower limbs and/or the vertebral column, leading to various degrees of flexion or extension limitations evident at birth. LCCS2 patients manifest craniofacial/ocular findings, lack of hydrops, multiple pterygia, and fractures, as well as a normal duration of pregnancy and a unique feature of a markedly distended urinary bladder (neurogenic bladder defect). The phenotype suggests a spinal cord neuropathic etiology.
Sequence Similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
Post-Translational Modification: Autophosphorylated (PubMed:20351256). Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778).
Cellular Location: Cell membrane.
Database Links:
  • Entrez Gene: 2065?Human
  • Entrez Gene: 13867?Mouse
  • Entrez Gene: 29496?Rat
  • Omim: 190151?Human
  • SwissProt: P21860?Human
  • SwissProt: Q61526?Mouse
  • SwissProt: Q62799?Rat
  • Unigene: 118681?Human
  • Unigene: 373043?Mouse
  • Unigene: 10228?Rat
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    Synonyms:
  • c erbB 3 Antibody
  • c erbB3 Antibody
  • Erb b2 receptor tyrosine kinase 3 Antibody
  • ErbB 3 Antibody
  • ERBB3 Antibody
  • ERBB3 protein Antibody
  • erbB3 S Antibody
  • ERBB3_HUMAN Antibody
  • Glial growth factor receptor Antibody
  • HER 3 Antibody
  • HER3 Antibody
  • Human epidermal growth factor receptor 3 Antibody
  • LCCS2 Antibody
  • MDA BF 1 Antibody
  • MGC88033 Antibody
  • p180 ErbB3 Antibody
  • p45 sErbB3 Antibody
  • p85 sErbB3 Antibody
  • proto-oncogene-like protein c ErbB 3 Antibody
  • proto-oncogene-like protein c ErbB3 Antibody
  • Proto-oncogene-like protein c-ErbB-3 Antibody
  • Receptor tyrosine protein kinase erbB 3 Antibody
  • Receptor tyrosine protein kinase erbB3 Antibody
  • Receptor tyrosine-protein kinase erbB-3 Antibody
  • Tyrosine kinase type cell surface receptor HER3 Antibody
  • Tyrosine kinase-type cell surface receptor HER3 Antibody
  • v erb b2 avian erythroblastic leukemia viral oncogene homolog 3 Antibody
  • v erb b2 erythroblastic leukemia viral oncogene homolog 3 Antibody
  • v erb b2 erythroblastic leukemia viral oncogene homolog 3 (avian) Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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