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Anti-ERAP1 (K467) Antibody

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产品名称: Anti-ERAP1 (K467) Antibody
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Anti-ERAP1 (K467) Antibody


Anti-ERAP1 (K467) Antibody  的详细介绍
Name: Anti-ERAP1 (K467) Antibody
See all ERAP1 primary antibodies
Description: Rabbit polyclonal antibody to ERAP1 (K467)
Specificity: ERAP1 (K467) pAb detects endogenous levels of ERAP1 protein.
Applications: WB, IHC, IF
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 435-489 of Human ERAP1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 110 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Function: Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.
Tissue Specificity: Ubiquitous.
Sequence Similarities: Belongs to the peptidase M1 family.
Post-Translational Modification: N-glycosylated.
Cellular Location: Endoplasmic reticulum membrane.
Database Links:
  • Entrez Gene: 51752?Human
  • Entrez Gene: 80898?Mouse
  • Entrez Gene: 80897?Rat
  • Omim: 606832?Human
  • SwissProt: Q9NZ08?Human
  • SwissProt: Q9EQH2?Mouse
  • SwissProt: Q9JJ22?Rat
  • Unigene: 716426?Human
  • Unigene: 83526?Mouse
  • Unigene: 22516?Rat
    		•
    Synonyms:
  • A LAP Antibody
  • A-LAP Antibody
  • Adipocyte derived leucine aminopeptidase Antibody
  • Adipocyte-derived leucine aminopeptidase Antibody
  • ALAP Antibody
  • Aminopeptidase PILS Antibody
  • Aminopeptidase regulator of TNFR1 shedding Antibody
  • APPILS Antibody
  • ARTS 1 Antibody
  • ARTS-1 Antibody
  • ARTS1 Antibody
  • Endoplasmic reticulum aminopeptidase 1 Antibody
  • Endoplasmic reticulum aminopeptidase associated with antigen processing Antibody
  • ERAAP Antibody
  • ERAAP1 Antibody
  • ERAP 1 Antibody
  • Erap1 Antibody
  • ERAP1_HUMAN Antibody
  • KIAA0525 Antibody
  • kiaa0525 protein Antibody
  • PILS AP Antibody
  • PILS-AP Antibody
  • PILSA Antibody
  • PILSAP Antibody
  • Puromycin insensitive leucyl specific aminopeptidase Antibody
  • Puromycin-insensitive leucyl-specific aminopeptidase Antibody
  • Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator Antibody
  • type 1 tumor necrosis factor receptors shedding aminopeptidase regulator Antibody
  • VEGF-induced aminopeptidase Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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