产品资料

Anti-ERAB (E135) Antibody

如果您对该产品感兴趣的话,可以
产品名称: Anti-ERAB (E135) Antibody
产品型号:
产品展商: 其它品牌
产品文档: 无相关文档

简单介绍

Anti-ERAB (E135) Antibody


Anti-ERAB (E135) Antibody  的详细介绍
Name: Anti-ERAB (E135) Antibody
See all ERAB primary antibodies
Description: Rabbit polyclonal antibody to ERAB (E135)
Specificity: ERAB (E135) pAb detects endogenous levels of ERAB protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 102-150 of Human ERAB.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 27 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. Catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD).
Tissue Specificity: Ubiquitously expressed in normal tissues but is overexpressed in neurons affected in AD.
Involvement in Disease: 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency: A disorder that leads to neurological abnormalities, including psychomotor retardation and, in virtually all patients, loss of mental and motor skills.

Mental retardation, X-linked, syndromic, 10: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRXS10 patients manifest mild mental retardation, choreoathetosis and abnormal behavior.

Mental retardation, X-linked 17: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations.
Sequence Similarities: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Cellular Location: Mitochondrion.
Database Links:
  • Entrez Gene: 3028?Human
  • Entrez Gene: 15108?Mouse
  • Entrez Gene: 63864?Rat
  • Omim: 300256?Human
  • SwissProt: Q99714?Human
  • SwissProt: O08756?Mouse
  • SwissProt: O70351?Rat
  • Unigene: 171280?Human
  • Unigene: 6994?Mouse
  • Unigene: 2700?Rat
    		•
    Synonyms:
  • 17 beta hydroxysteroid dehydrogenase 10 Antibody
  • 17 beta hydroxysteroid dehydrogenase type 10 Antibody
  • 17-beta-HSD 10 Antibody
  • 17-beta-hydroxysteroid dehydrogenase 10 Antibody
  • 17b HSD10 Antibody
  • 3 hydroxy 2 methylbutyryl CoA dehydrogenase Antibody
  • 3 hydroxyacyl CoA dehydrogenase type 2 Antibody
  • 3 hydroxyacyl CoA dehydrogenase type II Antibody
  • 3-hydroxy-2-methylbutyryl-CoA dehydrogenase Antibody
  • 3-hydroxyacyl-CoA dehydrogenase type II Antibody
  • 3-hydroxyacyl-CoA dehydrogenase type-2 Antibody
  • AB binding alcohol dehydrogenase Antibody
  • ABAD Antibody
  • Ads9 Antibody
  • Amyloid beta binding polypeptide Antibody
  • Amyloid beta peptide binding alcohol dehydrogenase Antibody
  • Amyloid beta peptide binding protein Antibody
  • CAMR Antibody
  • DUPXp11.22 Antibody
  • Endoplasmic Reticulum Amyloid Binding Protein Antibody
  • Endoplasmic reticulum associated amyloid beta peptide binding protein Antibody
  • Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Antibody
  • ER associated amyloid beta-binding protein Antibody
  • ERAB Antibody
  • HADH 2 Antibody
  • HADH2 Antibody
  • HCD 2 Antibody
  • HCD2 Antibody
  • HCD2_HUMAN Antibody
  • Hsd17b10 Antibody
  • Hydroxyacyl CoA Dehydrogenase type II Antibody
  • Hydroxyacyl Coenzyme A dehydrogenase type II Antibody
  • Hydroxysteroid (17 beta) dehydrogenase 10 Antibody
  • Mental retardation X linked syndromic 11 Antibody
  • MHBD Antibody
  • Mitochondrial L3 Hydroxyacyl CoA Dehydrogenase Antibody
  • Mitochondrial ribonuclease P protein 2 Antibody
  • Mitochondrial RNase P protein 2 Antibody
  • MRPP2 Antibody
  • MRX17 Antibody
  • SCHAD Antibody
  • SDR5C1 Antibody
  • Short chain dehydrogenase/reductase family 5C member 1 Antibody
  • Short chain L 3 hydroxyacyl CoA dehydrogenase type 2 Antibody
  • Short chain type dehydrogenase/reductase XH98G2 Antibody
  • Short-chain type dehydrogenase/reductase XH98G2 Antibody
  • Type 10 17b HSD Antibody
  • Type 10 17beta hydroxysteroid dehydrogenase Antibody
  • Type II HADH Antibody
  • XH98G2 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
    产品留言
    标题
    联系人
    联系电话
    内容
    验证码
    点击换一张
    注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
    2.如有必要,请您留下您的详细联系方式!

    沪公网安备 31011202007337号