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Anti-Epsin 1 Antibody

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产品名称: Anti-Epsin 1 Antibody
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简单介绍

Anti-Epsin 1 Antibody


Anti-Epsin 1 Antibody  的详细介绍
Name: Anti-Epsin 1 Antibody
See all Epsin 1 primary antibodies
Description: Rabbit polyclonal antibody to Epsin 1
Specificity: Epsin 1 Polyclonal Antibody detects endogenous levels of Epsin 1 protein.
Applications: WB, ELISA
Reactivity: Human, Mouse, Rat
Immunogen: Synthesized peptide derived from the Internal region of human Epsin 1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1mg / ml
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage: Store at -20˚C / 1 year
Function: Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis.
Sequence Similarities: Belongs to the epsin family.
Post-Translational Modification: Phosphorylated on serine and/or threonine residues in mitotic cells. Phosphorylation reduces interaction with REPS2, AP-2 and the membrane fraction. Depolarization of synaptosomes results in dephosphorylation.
Cellular Location: Cytoplasm. Cell membrane. Nucleus. Membrane > Clathrin-coated pit.

Associated with the cytoplasmic membrane at sites where clathrin-coated pits are forming. Colocalizes with clathrin and AP-2 in a punctate pattern on the plasma membrane. Detected in presynaptic nerve terminals and in Golgi stacks. May shuttle to the nucleus when associated with ZBTB16/ZNF145 (By similarity).
Database Links:
  • Entrez Gene: 29924 Human
  • Entrez Gene: 13854 Mouse
  • Entrez Gene: 117277 Rat
  • Omim: 607262 Human
  • SwissProt: Q9Y6I3 Human
  • SwissProt: Q80VP1 Mouse
  • SwissProt: O88339 Rat
  • Unigene: 279953 Human
  • Unigene: 3091 Mouse
  • Unigene: 30007 Rat
    		•
    Synonyms:
  • EH domain binding mitotic phosphoprotein Antibody
  • EH domain-binding mitotic phosphoprotein Antibody
  • EPN 1 Antibody
  • Epn1 Antibody
  • EPN1_HUMAN Antibody
  • EPS 15 interacting protein 1 Antibody
  • EPS-15-interacting protein 1 Antibody
  • Epsin 1 Antibody
  • Epsin-1 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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