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Anti-Eps15 Antibody

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产品名称: Anti-Eps15 Antibody
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Anti-Eps15 Antibody


Anti-Eps15 Antibody  的详细介绍
Name: Anti-Eps15 Antibody
See all Eps15 primary antibodies
Description: Rabbit polyclonal antibody to Eps15
Specificity: The antibody detects endogenous levels of total Eps15 protein.
Applications: WB
Reactivity: Human, Mouse
Immunogen: Synthetic peptide corresponding to a region within amino acids 832 and 896 of Eps15.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antibodies were purified by antigen-affinity chromatography.
Concentration: 0.83mg / ml
Formulation: Rabbit IgG in 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Storage: Store at -20˚C
Function: Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.
Tissue Specificity: Ubiquitously expressed.
Post-Translational Modification: Phosphorylation on Tyr-849 is involved in the internalization of EGFR. Not required for membrane translocation after EGF treatment or for targeting to coated pits, but essential for a subsequent step in EGFR endocytosis (By similarity). Phosphorylated on serine upon DNA damage, probably by ATM or ATR.
Cellular Location: Cytoplasm. Cell membrane. Membrane > Clathrin-coated pit.

Recruited to the plasma membrane upon EGFR activation and localizes to coated pits. Colocalizes with UBQLN1 in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments and in cytoplasmic juxtanuclear structures called aggresomes.
Database Links:
  • Entrez Gene: 2060 Human
  • Entrez Gene: 13858 Mouse
  • Omim: 600051 Human
  • SwissProt: P42566 Human
  • SwissProt: P42567 Mouse
  • Unigene: 83722 Human
  • Unigene: 318250 Mouse
    		•
    Synonyms:
  • AF 1P Antibody
  • AF 1p protein Antibody
  • AF1P Antibody
  • ALL1 fused gene from chromosome 1 Antibody
  • Epidermal growth factor receptor pathway substrate 15 Antibody
  • Epidermal growth factor receptor substrate 15 Antibody
  • EPS 15 Antibody
  • EPS15 Antibody
  • MLLT 5 Antibody
  • MLLT5 Antibody
  • Protein Eps 15 Antibody
  • Protein Eps15 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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