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Antibodies
Anti-Ephrin-B2 (Ab-330) Antibody
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产品名称:
Anti-Ephrin-B2 (Ab-330) Antibody
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简单介绍
Anti-Ephrin-B2 (Ab-330)
Antibody
Anti-Ephrin-B2 (Ab-330) Antibody
的详细介绍
Overview
Name:
Anti-Ephrin-B2 (Ab-330)
Antibody
See all Ephrin-B2 primary antibodies
Description:
Rabbit polyclonal antibody to Ephrin-B2 (Ab-330)
Specificity:
The antibody detects endogenous level of total Ephrin-B2 protein.
Applications:
WB, IF
Dilutions:
Western blotting: 1:500~1:1000 Immunofluorescence: 1:100~1:200
Reactivity:
Human, Mouse, Rat
Immunogen:
Peptide sequence around aa.328~332 (N-I-Y-Y-K) derived from Human Ephrin B (ephrin-B2).
Host:
Rabbit
Clonality:
Polyclonal
Conjugate:
Unconjugated
Purification:
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration:
1.0mg / ml
Predicted MW:
37kd
Formulation:
Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:
Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Target
Function:
Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.
Tissue Specificity:
Lung and kidney.
Sequence Similarities:
Belongs to the ephrin family.
Post-Translational Modification:
Inducible phosphorylation of tyrosine residues in the cytoplasmic domain.
Cellular Location:
Membrane.
Database Links:
Entrez Gene: 1948 Human
Entrez Gene: 13642 Mouse
Entrez Gene: 306636 Rat
Omim: 600527 Human
SwissProt: P52799 Human
SwissProt: P52800 Mouse
Unigene: 149239 Human
Unigene: 209813 Mouse
Synonyms:
EFN B2 Antibody
EFNB 2 Antibody
Efnb2 Antibody
EFNB2_HUMAN Antibody
Eph related receptor tyrosine kinase ligand 5 Antibody
EPH-related receptor tyrosine kinase ligand 5 Antibody
Ephrin B2 Antibody
Ephrin-B2 Antibody
EphrinB2 Antibody
EPLG 5 Antibody
EPLG5 Antibody
Htk L Antibody
HTK ligand Antibody
HTK-L Antibody
HTKL Antibody
LERK 5 Antibody
LERK-5 Antibody
LERK5 Antibody
Ligand of eph related kinase 5 Antibody
MGC126226 Antibody
MGC126227 Antibody
MGC126228 Antibody
OTTMUSP00000024973 Antibody
Information:
Target information shown above is from the UniProt Consortium.
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