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Antibodies
Anti-Ephrin A1 Antibody
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产品名称:
Anti-Ephrin A1 Antibody
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简单介绍
Anti-Ephrin A1
Antibody
Anti-Ephrin A1 Antibody
的详细介绍
Overview
Name:
Anti-Ephrin A1
Antibody
See all Ephrin A1 primary antibodies
Description:
Rabbit polyclonal antibody to Ephrin A1
Applications:
WB, IHC
Dilutions:
Western blotting: 1:500-1:3000 Immunohistochemistry: 1:100-1:500
Reactivity:
Human
Immunogen:
Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 178 of Ephrin A1
Host:
Rabbit
Clonality:
Polyclonal
Conjugate:
Unconjugated
Purification:
Purified by antigen-affinity chromatography.
Predicted MW:
24kd
Formulation:
Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
Storage:
Store at -20?C for long term preservation (recommended). Store at 4?C for short term use.
Target
Function:
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.
Tissue Specificity:
Brain. Down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells (at protein level).
Sequence Similarities:
Belongs to the ephrin family.
Post-Translational Modification:
Undergoes proteolysis by a metalloprotease to give rise to a soluble monomeric form.
Cellular Location:
Cell membrane.
Database Links:
Entrez Gene: 1942?Human
Omim: 191164?Human
SwissProt: P20827?Human
Unigene: 516664?Human
Synonyms:
B61 Antibody
ECKLG Antibody
EFL 1 Antibody
EFL1 Antibody
EFNA 1 Antibody
Efna1 Antibody
EFNA1_HUMAN Antibody
EPH related receptor tyrosine kinase ligand 1 Antibody
EPH-related receptor tyrosine kinase ligand 1 Antibody
Ephrin A1 Antibody
Ephrin-A1 Antibody
Ephrin-A1, secreted form Antibody
EphrinA1 Antibody
EPLG 1 Antibody
EPLG1 Antibody
Immediate early response protein B61 Antibody
LERK 1 Antibody
LERK-1 Antibody
LERK1 Antibody
Ligand of eph related kinase 1 Antibody
OTTHUMP00000033242 Antibody
OTTHUMP00000033271 Antibody
secreted form Antibody
TNF alpha-induced protein 4 Antibody
TNFAIP 4 Antibody
TNFAIP4 Antibody
Tumor necrosis factor alpha induced protein 4 Antibody
Tumor necrosis factor alpha-induced protein 4 Antibody
Information:
Target information shown above is from the UniProt Consortium.
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