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Anti-EphB6 (D881) Antibody

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产品名称: Anti-EphB6 (D881) Antibody
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Anti-EphB6 (D881) Antibody


Anti-EphB6 (D881) Antibody  的详细介绍
Name: Anti-EphB6 (D881) Antibody
See all EphB6 primary antibodies
Description: Rabbit polyclonal antibody to EphB6 (D881)
Specificity: EphB6 (D881) pAb detects endogenous levels of EphB6 protein.
Applications: WB, IHC, IF
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 851-900 of Human EphB6.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 119 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2.
Tissue Specificity: Expressed in brain. Expressed in non invasive breast carcinoma cell lines (at protein level). Strong expression in brain and pancreas, and weak expression in other tissues, such as heart, placenta, lung, liver, skeletal muscle and kidney. Expressed in breast non invasive tumors but not in metastatic lesions. Isoform 3 is expressed in cell lines of glioblastomas, anaplastic astrocytomas, gliosarcomas and astrocytomas. Isoform 3 is not detected in normal tissues.
Sequence Similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Post-Translational Modification: Ligand-binding increases phosphorylation on tyrosine residues. Phosphorylation on tyrosine residues is mediated by transphosphorylation by the catalytically active EPHB1 in a ligand-independent manner. Tyrosine phosphorylation of the receptor may act as a switch on the functional transition from cell adhesion/attraction to de-adhesion/repulsion.
Cellular Location: Membrane.
Database Links:
  • Entrez Gene: 2051?Human
  • Entrez Gene: 13848?Mouse
  • Entrez Gene: 312275?Rat
  • Omim: 602757?Human
  • SwissProt: O15197?Human
  • SwissProt: O08644?Mouse
  • SwissProt: P0C0K7?Rat
  • Unigene: 380089?Human
  • Unigene: 271976?Mouse
  • Unigene: 125930?Rat
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    Synonyms:
  • Eph receptor B6 Antibody
  • Ephb6 Antibody
  • EPHB6_HUMAN Antibody
  • Ephrin type B receptor 6 precursor Antibody
  • Ephrin type-B receptor 6 Antibody
  • HEP Antibody
  • MGC129910 Antibody
  • MGC129911 Antibody
  • Tyrosine protein kinase defective receptor EPH 6 Antibody
  • Tyrosine-protein kinase-defective receptor EPH-6 Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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