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Anti-EPHA1Antibody Antibody

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产品名称: Anti-EPHA1Antibody Antibody
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Anti-EPHA1Antibody Antibody


Anti-EPHA1Antibody Antibody  的详细介绍
Name: Anti-EPHA1Antibody Antibody
See all EPHA1Antibody primary antibodies
Description: Rabbit polyclonal antibody to EPHA1Antibody
Specificity: The antibody detects endogenous levels of total EPHA1protein.
Applications: WB, IF
Reactivity: Human
Immunogen: Synthesized peptide derived from internal of human EPHA1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1.0mg / ml
Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20˚C
Function: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.
Tissue Specificity: Overexpressed in several carcinomas.
Sequence Similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Post-Translational Modification: Phosphorylated. Autophosphorylation is stimulated by its ligand EFNA1.
Cellular Location: Cell membrane.
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