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Anti-ENPP2 Antibody

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产品名称: Anti-ENPP2 Antibody
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Anti-ENPP2 Antibody


Anti-ENPP2 Antibody  的详细介绍
Name: Anti-ENPP2 Antibody
See all ENPP2 primary antibodies
Description: Rabbit polyclonal antibody to ENPP2
Specificity: The antibody detects endogenous level of total ENPP2 polyclonal antibody.
Applications: IHC
Reactivity: Human
Immunogen: Recombinant human Ectonucleotide pyrophosphatase / phosphodiesterase family member 2 protein (564-863aa)
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen Affinity Purified
Concentration: 1.0mg / mL
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20?C
Function: Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor.
Tissue Specificity: Predominantly expressed in brain, placenta, ovary, and small intestine. Expressed in a number of carcinomas such as hepatocellular and prostate carcinoma, neuroblastoma and non-small-cell lung cancer. Expressed in body fluids such as plasma, cerebral spinal fluid (CSF), saliva, follicular and amniotic fluids. Not detected in leukocytes. Isoform 1 is more highly expressed in peripheral tissues than in the central nervous system (CNS). Adipocytes only express isoform 1. Isoform 3 is more highly expressed in the brain than in peripheral tissues.
Sequence Similarities: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
Post-Translational Modification: N-glycosylation, but not furin-cleavage, plays a critical role on secretion and on lysoPLD activity.
Cellular Location: Secreted.

Secreted by most body fluids including serum and CSF. Also by adipocytes and numerous cancer cells.
Database Links:
  • Entrez Gene: 5168?Human
  • Omim: 601060?Human
  • SwissProt: Q13822?Human
  • Unigene: 190977?Human
    		•
    Synonyms:
  • ATX Antibody
  • ATX X Antibody
  • Autotaxin Antibody
  • Autotaxin t Antibody
  • E NPP 2 Antibody
  • E-NPP 2 Antibody
  • Ectonucleotide pyrophosphatase/phosphodiesterase 2 Antibody
  • Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Antibody
  • ENPP2 Antibody
  • ENPP2_HUMAN Antibody
  • Extracellular lysophospholipase D Antibody
  • FLJ26803 Antibody
  • LysoPLD Antibody
  • NPP2 Antibody
  • PD IALPHA Antibody
  • PDNP2 Antibody
  • Phosphodiesterase I alpha Antibody
  • Phosphodiesterase I/nucleotide pyrophosphatase 2 Antibody
  • Plasma lysophospholipase D Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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