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Anti-ELF4 Antibody

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产品名称: Anti-ELF4 Antibody
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简单介绍

Anti-ELF4 Antibody


Anti-ELF4 Antibody  的详细介绍
Name: Anti-ELF4 Antibody
See all ELF4 primary antibodies
Description: Rabbit polyclonal antibody to ELF4.
Applications: WB, IHC, IF
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:100.
Reactivity: Human
Immunogen: Recombinant protein of human ELF4.
Protein Length: 663
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2 (By similarity). Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway.
Tissue Specificity: Abundantly expressed in the placenta and in a variety of myeloid leukemia cell lines. Moderate levels of expression in heart, lung, spleen, thymus, peripheral blood lymphocytes, ovary and colon. Lower levels of expression in Jurkat T-cells and other T-cell lines and no expression in brain.
Sequence Similarities: Belongs to the ETS family.
Cellular Location: Nucleus > PML body.

Accumulation into PML nuclear bodies is mediated by PML.
Database Links:
  • Entrez Gene: 2000?Human
  • SwissProt: Q99607?Human
  • Unigene: 271940?Human
    		•
    Synonyms:
  • E74-like factor 4 Antibody
  • ELF4 Antibody
  • Elf4/MEF Antibody
  • ELF4_HUMAN Antibody
  • ELFR Antibody
  • ETS-related transcription factor Elf-4 Antibody
  • ETS-related transcription factor Elf4 Antibody
  • MEF Antibody
  • Myeloid Elf-1-like factor Antibody
  • Myeloid Elf1-like factor Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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