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Anti-ELF3 Antibody

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产品名称: Anti-ELF3 Antibody
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简单介绍

Anti-ELF3 Antibody


Anti-ELF3 Antibody  的详细介绍
Name: Anti-ELF3 Antibody
See all ELF3 primary antibodies
Description: Rabbit polyclonal antibody to ELF3
Specificity: The antibody detects endogenous level of total ELF3 antibody.
Applications: WB, IF
Reactivity: Human, Rat
Immunogen: Recombinant protein of human ELF3.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antibodies were purified by affinity purification using immunogen.
Concentration: 1.0mg / ml
Formulation: Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20˚C
Function: Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity).
Tissue Specificity: Expressed exclusively in tissues containing a high content of terminally differentiated epithelial cells including mammary gland, colon, trachea, kidney, prostate, uterus, stomach and skin.
Sequence Similarities: Belongs to the ETS family.
Cellular Location: Cytoplasm. Nucleus.

Localizes to the cytoplasm where it has been shown to transform MCF-12A mammary epithelial cells via a novel cytoplasmic mechanism. Also transiently expressed and localized to the nucleus where it induces apoptosis in non-transformed breast epithelial cells MCF-10A and MCF-12A via a transcription-dependent mechanism.
Database Links:
  • Entrez Gene: 1999 Human
  • Entrez Gene: 304815 Rat
  • Omim: 602191 Human
  • SwissProt: P78545 Human
  • SwissProt: Q4V7E1 Rat
  • Unigene: 603657 Human
  • Unigene: 67928 Human
  • Unigene: 3063 Rat
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    Synonyms:
  • E74 like factor 3 Antibody
  • E74 like factor 3 ets domain transcription factor Antibody
  • E74 like factor 3 ets domain transcription factor epithelial specific Antibody
  • E74 like factor 3 ETS domain transcription factor serine box epithelial specific Antibody
  • E74-like factor 3 Antibody
  • Elf3 Antibody
  • ELF3_HUMAN Antibody
  • Epithelial restricted with serine box Antibody
  • Epithelial-restricted with serine box Antibody
  • Epithelium restricted Ets protein ESX Antibody
  • Epithelium specific Ets factor 1 Antibody
  • Epithelium specific Ets transcription factor 1 Antibody
  • Epithelium-restricted Ets protein ESX Antibody
  • Epithelium-specific Ets transcription factor 1 Antibody
  • EPR 1 Antibody
  • EPR1 Antibody
  • ERT Antibody
  • ESE-1 Antibody
  • ESE1 Antibody
  • ESX Antibody
  • Ets domain transcription factor serine box Antibody
  • Ets domain transcription factor serine box epithelial specific Antibody
  • Ets transcription factor Antibody
  • ETS-related transcription factor Elf-3 Antibody
  • jen Antibody
  • MGC139318 Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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