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Anti-eIF6 Antibody

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产品名称: Anti-eIF6 Antibody
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简单介绍

Anti-eIF6 Antibody


Anti-eIF6 Antibody  的详细介绍
Name: Anti-eIF6 Antibody
See all eIF6 primary antibodies
Description: Rabbit polyclonal antibody to eIF6
Specificity: EIF6 pAb detects endogenous levels of EIF6 protein.
Applications: WB, IHC, IF
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant full length Human eIF6.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 27 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.
Function: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity (PubMed:10085284, PubMed:14654845, PubMed:21536732). In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis (By similarity). Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:17507929). Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth (By similarity).
Tissue Specificity: Expressed at very high levels in colon carcinoma with lower levels in normal colon and ileum and lowest levels in kidney and muscle (at protein level).
Sequence Similarities: Belongs to the eIF-6 family.
Post-Translational Modification: Phosphorylation at Ser-174 and Ser-175 by CSNK1D/CK1 promotes nuclear export.
Cellular Location: Cytoplasm. Nucleus > Nucleolus.

Shuttles between cytoplasm and nucleus/nucleolus.
Database Links:
  • Entrez Gene: 3692?Human
  • Entrez Gene: 16418?Mouse
  • Entrez Gene: 305506?Rat
  • Omim: 602912?Human
  • SwissProt: P56537?Human
  • SwissProt: O55135?Mouse
  • SwissProt: Q3KRD8?Rat
  • Unigene: 654848?Human
  • Unigene: 271674?Mouse
  • Unigene: 190833?Rat
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    Synonyms:
  • b(2)gcn Antibody
  • B(2)GCN homolog Antibody
  • B4 integrin interactor Antibody
  • Binding protein of beta-4 integrin Antibody
  • CAB Antibody
  • eIF-6 Antibody
  • EIF3A Antibody
  • EIF6 Antibody
  • Eukaryotic translation initiation factor 3A Antibody
  • Eukaryotic translation initiation factor 6 Antibody
  • IF6_HUMAN Antibody
  • Integrin beta 4 binding protein Antibody
  • ITGB4BP Antibody
  • OK/SW-cl.27 Antibody
  • p27 beta 4 integrin binding protein Antibody
  • p27(BBP) Antibody
  • p27BBP Antibody
  • RP4-614O4.1 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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