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Anti-EIF5A Antibody

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产品名称: Anti-EIF5A Antibody
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简单介绍

Anti-EIF5A Antibody


Anti-EIF5A Antibody  的详细介绍
Name: Anti-EIF5A Antibody
See all EIF5A primary antibodies
Description: Goat polyclonal antibody to EIF5A.
Applications: ELISA, WB
Reactivity: Human
Immunogen: Synthetic peptide corresponding to Human EIF5A (internal region).
Sequence: C-RPPHRASFLKRLESK
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 µg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts.
Tissue Specificity: Expressed in umbilical vein endothelial cells and several cancer cell lines (at protein level).
Sequence Similarities: Belongs to the eIF-5A family.
Post-Translational Modification: Acetylated. Deacetylated by SIRT2.
Cellular Location: Cytoplasm. Nucleus. Endoplasmic reticulum membrane. Nucleus > Nuclear pore complex.

Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions.
Biotechnological Use: Mature eIF5A-1 may be used as an in situ diagnostic marker for aberrant proliferation in intraepithelial neoplasia of the vulva.
Database Links:
  • Entrez Gene: 1984 Human
  • Omim: 600187 Human
  • SwissProt: P63241 Human
  • Unigene: 534314 Human
  • Unigene: 729454 Human
    		•
    Synonyms:
  • eIF 4D Antibody
  • EIF 5A Antibody
  • eIF 5A 1 Antibody
  • eIF 5A1 Antibody
  • eIF-4D Antibody
  • eIF-5A Antibody
  • eIF-5A-1 Antibody
  • eIF-5A1 Antibody
  • eIF4D Antibody
  • eIF5A Antibody
  • EIF5A1 Antibody
  • eIF5AI Antibody
  • Eukaryotic initiation factor 5A Antibody
  • Eukaryotic initiation factor 5A isoform 1 Antibody
  • Eukaryotic translation initiation factor 5A Antibody
  • Eukaryotic translation initiation factor 5A 1 Antibody
  • Eukaryotic translation initiation factor 5A-1 Antibody
  • IF5A1_HUMAN Antibody
  • MGC104255 Antibody
  • MGC99547 Antibody
  • Rev binding factor Antibody
  • Rev-binding factor Antibody
  • uORF Antibody
  • uORF A Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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