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Anti-EIF4EBP1 Antibody

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产品名称: Anti-EIF4EBP1 Antibody
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简单介绍

Anti-EIF4EBP1 Antibody


Anti-EIF4EBP1 Antibody  的详细介绍
Name: Anti-EIF4EBP1 Antibody
See all EIF4EBP1 primary antibodies
Description: Rabbit polyclonal antibody to EIF4EBP1
Specificity: The antibody detects endogenous levels of total EIF4EBP1 protein.
Applications: WB, IHC
Reactivity: Human
Immunogen: Fusion protein corresponding to residues near the N terminal of human eukaryotic translation initiation factor 4E binding protein 1
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 2mg / ml
Formulation: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage: Store at -20?C
Function: Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
Sequence Similarities: Belongs to the eIF4E-binding protein family.
Post-Translational Modification: Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF. Phosphorylation at Thr-37, Thr-46, Ser-65 and Thr-70, corresponding to the hyperphosphorylated form, is regulated by mTORC1 and abolishes binding to EIF4E.
Database Links:
  • Entrez Gene: 1978?Human
  • Omim: 602223?Human
  • SwissProt: Q13541?Human
  • Unigene: 411641?Human
    		•
    Synonyms:
  • 4E-BP1 Antibody
  • 4EBP1 Antibody
  • 4EBP1_HUMAN Antibody
  • BP 1 Antibody
  • eIF4E binding protein 1 Antibody
  • eIF4E-binding protein 1 Antibody
  • eIF4EBP1 Antibody
  • Eukaryotic translation initiation factor 4E-binding protein 1 Antibody
  • PHAS-I Antibody
  • PHASI Antibody
  • Phosphorylated heat- and acid-stable protein regulated by insulin 1 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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