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Anti-eIF4B (phospho-Ser422) Antibody

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产品名称: Anti-eIF4B (phospho-Ser422) Antibody
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Anti-eIF4B (phospho-Ser422) Antibody


Anti-eIF4B (phospho-Ser422) Antibody  的详细介绍
Name: Anti-eIF4B (phospho-Ser422) Antibody
See all eIF4B primary antibodies
Description: Rabbit polyclonal antibody to eIF4B (phospho-Ser422)
Specificity: The antibody detects endogenous level of eIF4B only when phosphorylated at Serine 422.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Peptide sequence around phosphorylation site of Serine 422 (T-G-S(p)-E-S) derived from Human eIF4B.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration: 1.0mg / ml
Formulation: Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Function: Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.
Post-Translational Modification: Phosphorylated at Ser-422 by RPS6KA1 and RPS6KB1; phosphorylation enhances the affinity of EIF4B for the EIF3 complex.
Database Links:
  • Entrez Gene: 1975?Human
  • Entrez Gene: 75705?Mouse
  • Entrez Gene: 300253?Rat
  • Omim: 603928?Human
  • SwissProt: P23588?Human
  • SwissProt: Q8BGD9?Mouse
  • Unigene: 648394?Human
  • Unigene: 702041?Human
  • Unigene: 290022?Mouse
  • Unigene: 391795?Mouse
  • Unigene: 95954?Rat
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    Synonyms:
  • 2310046H11Rik Antibody
  • AL024095 Antibody
  • C85189 Antibody
  • EIF 4B Antibody
  • eIF-4B Antibody
  • eIF4B Antibody
  • Eukaryotic initiation factor 4B Antibody
  • Eukaryotic translation initiation factor 4B Antibody
  • IF4B_HUMAN Antibody
  • PRO1843 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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