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Anti-eIF3ζ (R135) Antibody

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产品名称: Anti-eIF3ζ (R135) Antibody
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Anti-eIF3ζ (R135) Antibody


Anti-eIF3ζ (R135) Antibody  的详细介绍
Name: Anti-eIF3ζ (R135) Antibody
See all eIF3ζ primary antibodies
Description: Rabbit polyclonal antibody to eIF3ζ (R135)
Specificity: eIF3ζ (R135) pAb detects endogenous levels of eIF3ζ protein.
Applications: WB, IHC
Reactivity: Human, Mouse
Immunogen: Synthetic peptide, corresponding to amino acids 111-160 of Human eIF3ζ.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 64 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs (PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:18599441, PubMed:25849773). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs (PubMed:27462815).
Sequence Similarities: Belongs to the eIF-3 subunit D family.
Cellular Location: Cytoplasm.
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